Digital Asset DirectAmesite Inc.
Contact Details Amesite, Inc. +1 734-876-8141 info@amesite.com Company Website http://www.amesite.io
December 27, 2022 08:00 AM Eastern Standard Time
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News ReleaseWriting Solutions
Are you looking for a professional essay writing service that delivers quality content reliably? If so, you are not alone. Many people are choosing to buy essay writing services, especially as more people attend university or college and realize they simply don’t have time to get everything done. There are many reasons to use these types of services. You might be too busy with final exams or work to get your essays done on time. Using an essay writing service can actually save you time, energy and mental strength for more important ventures, like work. You can also use these services to help give you a better idea of what a great essay on a certain subject looks like, so that you can improve your own writing in the future. Or you can use these services for essays in unimportant subjects, so that you can redirect your primary focus towards your major. Regardless of why you want someone to write your essay, there is one hard truth to face: it can be surprisingly hard to find the best essay writing service. Some companies delivery poor quality results, don’t cover the subject you need, or they don’t even deliver at all and scam you out of your money. How do you tell the “dud” companies from the professional companies? Look no further than this guide. We understand how hard it is to find a great essay writing service, which is why we’ve prepared this guide to the best essay writing services that you’ll find today. These are reliable, legitimate websites that will deliver quality results on time, every time. If you’re ready to take some weight off your academic shoulders, take a look at the following guide that will help you find writing services to suit your needs in 2023. Looking for a quick fix? Here is our top 7 list. 99Papers - the absolute best essay writing service to use in 2023. PaperHelp - a highly rated writing company based in the USA. 1Essay - professional college paper writers to hire Studdit - newest website with TOP writers EssayPro - cheap essay writing company EssayBox - one of the best website to buy essays online MyAdmissionEssay - write my admission essay provider. Ready to find out more about these great services? Read on to explore their reviews! The List of 7 Best Essay Writing Services 2022/23 1. 99Papers 99Papers is the top essay writing service out there today. They provide customizable essay writing services and a money back guarantee that will make you feel at ease about buying essays from them. Features 99Papers features a 100% money-back guarantee if you're not satisfied with your essay, along with a plagarism-free guarantee. 99Papers uses special software to detect plagiarism. This is especially critical in today’s digital world. How it Works 99Papers is very easy to use. First, you provide the website with the basic information about your essay: what type of essay it is (such as academic essay versus general essay); the academic level; the deadline; and how many pages the essay needs to be. 99Papers estimates 275 words per page, so keep this in mind. Once you provide the service with this information, they will get back to you with a confirmation of the price for your content. If you want to move forward, you can pay and the order will start. If you’d like, you can talk to the writer assigned to your essay. This will help you to make sure that the writer understands what you need from your essay. They can even provide you with an outline of the work. The final draft of the essay will be sent to you for approval before the deadline. Once you accept it, you can download it. Pricing 99Papers pricing will vary depending on factors like the type of essay; academic level; deadline; and page number. Their high school level essay writing starts at $9.95 per page for essays due in more than 15 days; and goes all the way to $55.50 per page for PhD level writing that is due within 3 hours. The website provides a handy chart and pricing calculator that is easy to use. From January 2023 you can use promo code D1HV77R8 to get 5% discount on your order. 99Papers Customer Review "I chose 99Papers to write my essay because of the good reviews I found online. I really liked how customized the entire process was, and the fact that I could talk to the writer who was working on my essay. I let them know about a few stylistic things I’d like in my essay, and they were accommodating for that. I also liked that I didn’t feel blindsided by the essay quality. I got an outline and approved it, and got to approve the final draft. I was worried I might need to request a refund because I’d never used them before, but the quality was great!" 2. PaperHelp PaperHelp is a top essay writing service company in the United States with plenty of features. Features PaperHelp has some unique features. These include optional paid extras that can improve your experience. Their optional extras included: VIP customer support; #1 priority in customer support and fast feedback; Plagiarism report; a report proving that the paper does not contained plagiarism; Abstract page; an abstract for content that requires it; Sources; a report providing sources used for the essay; Outline or table of contents; formatted TOC or outline for the essay; Editor checking; extra proofreading from an expert editor; Charts; charts and graphics; Writer category; choosing a writer from PaperHelp's writing categories, Basic, Advanced and TOP. How it Works The PaperHelp order process is straightforward. You provide the service with information using their provided form, which requires you to tell them the type of paper, page number, and deadline. You must also explain the essay's requirements with as much detail as possible. Then, you submit this information with a valid email. Your email will be used to log into the website, and you can pay from there. Then, you can track and manage your order using the website or app. Pricing PaperHelp's pricing will vary depending on a few factors, including the deadline, academic level, and pages required for the essay. Pricing starts at $10 per page for high school writing and a minimum $21 per page for professional writing. Best price you can get at February 2023 with Happy New Year discount codes from the service main page. One unique element of PaperHelp's pricing is that you can choose between three different types of writers, which can also influence the price. Basic writers are standard writers. Advanced writers are native English writers who are considered the top in a particular field. And TOP writers are native English writers who have the best ratings. The optional features explained above are also available for an additional cost. For instance, the VIP customer support extra is an additional $14.99. PaperHelp Customer Review "I was nervous about having an essay writing on a complex topic, but I decided to give PaperHelp a try. Overall, I was really impressed. I felt their prices were fair, especially considering the complex nature of my essay. It was delivered on time. I really liked that there was an app I could use to keep track of my order, it made things a lot easier. I found out you actually get discounts for using their service more than once, and since I was satisfied with my essay, I’ll definitely be going back for more in the future." 3. 1Essay 1Essay is a quality essay writing company known for providing more affordable essays compared to its counterparts. Features 1Essay does not have a lot of frills, but this is reflected in the affordable pricing. Their primary features include customer service support that is available 24 hours a day, seven days a week. Customer service can provide you with updates on your order or help you with anything you need. Other features include profiles of the writers which can provide you with credentials. These are available upon request only. How it Works Ordering from 1Essay simple. First, you fill out their inquiry form on their website. This form asks you to clarify the type of essay, the academic level, and the deadline. After you send in this inquiry, you can provide additional information so that the website service can confirm a price quote for you. You can connect with the writer at anytime, in case you wanna check with the progress of your essay or to provide some additional information such as notes or stylistic choices. Your essay will then be delivered before the deadline so that you can approve it and to make sure you will have it in time period in time. Pricing 1Essay’s pricing starts at $9 per page for high school writing and a minimum of $25 for PhD level writing. The pricing will vary depending on the deadline; it might also vary depending on the type of essay and topic. 1Essay Customer Review "I was a bit nervous because there weren't many features that I am used to seeing on other writing service websites. However, the S I received was really great quality, especially considering the price was blower. Despite the lower price, the writing was really high quality and professional. I felt the writer really understood the subject and the assignment." 4. Studdit Studdit is a homework help website that includes essay writing services. Features The most unique feature of this website is the ability to use free revisions. These will ensure that your SA meets your needs even before it is finished. They also provide rush services for an additional fee, for those days when you need an essay done fast. How it Works Ordering an essay from this website is fairly straightforward. First, use the order inquiry form to provide the website with essential information about your essay. This includes the academic level, the deadline and the page number. Keep in mind that your final quote may be different depending on any extras you order or the overall complexity of your essay. You can check on your order while it is being written and processed. You get at least one free revision with your purchase price. Once it is approved, you can download it. Don’t forget to rate your writer afterwards. If you like the writer, you can even add them to your favourites. Pricing Studdit’s pricing starts at $10 per page for high school writing and $21 per page for professional writing, or writing for Master’s Degree and higher. The closer the deadline, the higher the price. Studdit Customer Review "Studdit was really helpful in getting my essay done on time and professionally. Even though the topic was difficult, I feel like the writer did enough research to make it sound well-researched and thought out. I also liked that it was delivered on time, so I didn't have to worry about it being late. The website was easy to use and when I reached out to customer service for some help, I got a fast reply." 5. EssayPro EssayPro is the cheapest essay writing service with dedicated writers and great customer service. Features This service offers a few additional features, such as optional plagiarism reports for an additional fee. The most notable feature is the ability to choose the writer you want for your essay. After you choose a writer, you make a payment deposit. You only finish payment after your essay has been finished and approved. How it Works Using the services simple. First, you need to provide them with the basic information about the essay you need written. This includes the deadline, page number as well as the academic level period from there, your order inquiry will be approved with a final price quote. Then, you choose your writer and make a payment deposit. Once the essay is finished and you have approved it, you can download it for your use. You can always contact customer service during the order. If you have any questions. Pricing EssayPro’s writing starts from $10.80 per page. The pricing can vary considerably depending on the academic level, topic and deadline. EssayPro Customer Review "The best writing service I’ve used. I really liked how simple the order process was, because I didn’t have time to fuss around. The prices were fair, especially considering the high quality of the essay I received. I really feel that this service employs the best professional writers, even on niche topics that are somewhat difficult to understand." 6. EssayBox EssayBox provides quality essays at affordable prices. Features EssayBox has several unique features. One of the services most unique features is its originality reports. These reports ensure that your essay is original and won’t be considered plagiarism. Other features including free title pages, free outlines, free bibliographies, and free revisions. How it Works First, you provide the service with the basic information about the essay you need written. This includes academic level, deadline and page count. Once they have approved this information, you’ll be provided with a confirmed price quote. If you would like to move forward, make your payment and a writer will start working on your essay as soon as possible. You can check on the content while it is being written, and request revisions during or after the essay is finished so that it meets your needs. Pricing Prices start at $12 per page for high school writing or $28per page for PhD writing; this is within 15 day+ deadlines. Promo code F96MZSFW for 5% will be valid from March to May 2023. EssayBox Customer Review "Wow! I can’t believe how quickly they got my essay done. I’m so glad I chose the service, because I was really in a pinch. Not only did they get my essay to me on time, but it was well written and exactly what I needed. I will definitely use their services in the future, especially if I have something that needs to be done quickly. I also appreciated how prompt their customer service was when I reached out with my inquiry." 7. MyAdmissionEssay MyAdmissionEssay is a writing service that specializes in admission’s essays. Features In addition to regular writing services, the service specializes in admissions essays. Their features include a loyalty program that can provide you with bonuses and discounts, along with the ability to choose writers in different categories. How it Works First, you provide the service with the basic information about your essay or admissions essay. Then, you’ll be provided with a firm price quote. If you move forward, you can contact the writer you choose during the writing process to ensure that you are on the same page. After the essay is finished, and you approve it, you can download it for your use. Pricing Pricing for admissions essays starts at $20 per page for essays due in 20 days or longer. Pricing for regular essays starts at $11 per page for high school and $19 per page for professional. MyAdmissionEssay Customer Review "I use them for my admissions essay and I couldn’t be happier. They delivered it on time and I felt that the ability to choose a more professional writer helped me to get better content overall." Frequently Asked Questions The following are the most frequently asked questions about getting an essay written. How much does it cost to buy an essay online? If you tell an essay writing service, simply, “I want you to write my essay, what is your price?” then you’re not likely to get a clear answer. The reason for this is because the cost of getting an essay written online can vary depending on numerous factors. The most important factors to consider are: academic level, amount of pages, and deadline. The higher the academic level - think high school to postgraduate - the higher the price. This is because it takes more experienced, professional and knowledgeable writers to create content for college-level topics than writing intended for a high school essay. Most essay writing services will price their essays “per page,” meaning you need to multiply the page count by this price. For instance, if a service charges $10 per page for a high school essay and the essay needs to be 8 pages, the price would be $80 as a base rate. Finally, you need to consider the deadline. The sooner you need your essay delivered, the more it is going to cost due to the rush service. The amount that a company charges for a rush service will vary on the company and how quickly you need the essay. As a general rule, expect to spend anywhere from $10 to $50 per page for an essay, with the above factors in mind. Are essay writing services legitimate in the United States in 2023? They can be. The key to ensuring that the essay writing service that you’re using is legitimate is to do some research. Only purchase from websites with authentic reviews, and always look up the company on several websites to make sure that it’s legitimate. Of course, the top 7 writing services that we’ve listed are all known for providing legitimate work. But if you do decide to venture to other services, especially newer ones, it’s important to do some research in order to avoid being scammed. There are several things to consider when you are trying to decide if a writing service is legitimate. First, how new is the service? If it’s not established, you’ll have to try harder to find out information or to look for reviews. Always take a look at the legitimate reviews posted outside of the website, such as on social media or independent blogs. What do these buyers say? People are more likely to be honest with reviews when they’re posted outside the service’s website. Another thing to consider is the overall clarity of the website. Does the service offer information about who they are, why they are qualified to write essays, and what prices they charge? If so, they are more likely to be legitimate. What are the simple steps to order an essay online? It can be daunting to order a written essay online, but once you understand the process that most of these writing services use, you’ll be an expert in no time. The first thing you need to do is gather all of the information about the essay you need written. This includes the academic level, the topic, the page number, and the deadline. You should also keep any special requirements handy. For instance, if your essay needs to be written in a certain format, this is information the website service will need to know. Next, you’ll need to choose the essay writing service you want to order from; ideally, consider one of the top 7 services we’ve listed and reviewed, as these are the best options for essay writing in 2023. Then, contact the writing service through their ordering page. This may involve submitting a form or otherwise providing the service with the necessary information. Once you’re on the website’s checkout page, you can confirm the total cost and make your payment. After that, all you need to do is wait for your essay to be written and delivered. It should be noted that you should keep an eye on the email you used for this order, just in case the writing service needs additional information to complete your essay. What is the best essay writing service in 2023? 99Papers is the best essay writing service to use in 2023. They have experienced, professional writers who work with you to ensure that your essay meets the criteria that you need. Although other services may still provide quality content, if you’re looking for the best of the best, then this is the company you should choose. A highly customizable process helps to ensure that you match with a writer who can deliver a high quality essay on time period their pricing may be a bit higher than some of the other services, but the high quality you receive is well worth the trade off. Another great element of 99Papers is the fact that they have a money back guarantee. This can help ease your mind if you are worried about the quality of the essay you will receive. In addition to this, there are plagiarism detector will make sure that your essay features no plagiarism and is authentically written. If you are looking for an essay writing service that truly has it all, you can do no better than 99Papers. Quality essays, reliable service, and a very customizable order experience all help this website to stand out from the rest. What is the best website to hire college paper writer in USA? PapersHelp is the best website to hire a college paper writer based in the USA. Their content is high quality, delivered on time and they understand the college essay writing process better than many other services. When you are looking to hire an essay writing service, it is critical that you choose someone who knows what they are doing. The features offered by the service also make it an exceptional choice when it comes to getting a college essay written. If you were looking for an essay writing service that specializes in college essay writing, while also being based in the USA, this is the best option. What is the cheapest essay writing company worldwide? EssayPro is the cheapest option when it comes to essay writing. If you’re looking for an essay writer that provides quality content without breaking the bank, then this is an excellent choice. Although they don’t offer as many frills as other essay writing services, they still provide quality content that is delivered on time. If you were looking for an essay writing service that offers great content that meets your needs, this is definitely the most affordable option. Remember, you won’t be getting as many features as you would with other websites, but this is the trade off for paying less money overall. U.S. colleges with the hardest requirements for an essay writing Every college or university has different requirements when it comes to essay writing for their students. Some colleges place hardly no emphasis on essay writing at all, while others have difficult requirements that can put a lot of pressure on students to perform well in their essays. The following are the top U.S. colleges with the hardest requirements for essay writing in 2023, along with a note about what makes them so hard. University of Michigan University of Michigan requires a total of 4 admissions essays, including 3 supplementary essays. These essays are known for their tough questions. University of Notre Dame The University of Notre Dame requires a total of 4 admission essays, including 3 supplemental essays with difficult, often philosophical questions. Amherst College Amherst College is known for its rigorous admission essay requirements; the essay prompts are based on quotes provided by previous or existing Amherst students. Applications can also choose to submit exceptional, existing graded papers from previous schooling. Brown University Brown requires 4 admissions essays that involve research and intimate knowledge of Brown University. Tufts University Tufts has difficult but creative admission essays that are challenging to applicants. California Institute of Technology CIT requires a total of 8 admissions essays with diverse, engaging but tough prompts. Massachusetts Institute of Technology MIT requires applications to complete a total of 5 admissions essays that require research and thoughtful consideration. University of Chicago The University of Chicago is known for requiring 3 supplemental essays with very creative prompts that can be difficult to answer. Princeton University Princeton will require four essays, including a regular admissions essay. The prompts are often personal, while requiring deep thought. Stanford University Stanford University has a very rigorous application process which requires numerous tests, transcripts, and reports. They also require a total of 11 supplemental admissions essays with creative, engaging but very challenging prompts. The high number of essays, along with the additional application requirements, is largely what makes Stanford’s essay requirements so difficult. Final Thoughts There are many reasons why you might choose to use an essay writing service. You might need help with a difficult topic or an admissions essay; you could be swamped from work and need someone else to take the weight off your shoulders; or you simply want to buy an essay because you don’t feel like writing your essay at the moment. Whatever your reason for wanting to find the best essay writing service, it’s important to keep a few things in mind. One, if at all possible, use one of the services discussed in the article above. These websites provide the best services at reasonable rates, and you’ll find that they are highly reliable and will meet your needs every time. Two, make sure you have all of your essay information ready before you start comparing prices across the different services. This will make it easier to input your information to get a price quote, and you’ll spend less time trying to find information like your page count or requirements. Three, remember that you’ll need to pay more money for different types of writing. Buying an essay intended for high school is going to cost you less than an essay for college or a post-graduate level; the pricing can also be impacted by when you need it by, as well as the page count. Finally, remember to always do your research before you commit to purchasing an essay from any essay writing service. When you do roper research, you’ll be able to eliminate sketchy websites that deliver low quality results--or don’t deliver at all. For best results, stick with experienced, legitimate websites that have great reviews and employ professional writers that know what they’re doing. We highly recommend that, if you’re ready to buy an essay, you should strongly consider using one of the top 7 best essay writing service companies updated in December 2022 and listed above for using in the next year. Contact Details Will Collins contact@legitwritingservice.com Company Website https://legitwritingservice.com
December 22, 2022 06:02 PM Eastern Standard Time
News ReleaseYourUpdateTV
A video accompanying this announcement is available at: https://youtu.be/v8cdWdNaAkM RSV, covid and flu are keeping kids out of school—parents out of work and unable to gather with their families. We are in the height of the Holiday travel season with sick children and now, older adults filling hospitals nationwide Flu and RSV usually circulates from late December to mid-February. But this year, an early spike in cases is resulting in markedly higher numbers of infections and hospitalizations. More importantly, RSV infections among young children and now older adults are filling many U.S. hospitals to capacity. On average, RSV leads to 58,000 hospitalizations among children under age 5 and 177,000 hospitalizations among adults 65 and older each year, according to the U.S. Centers for Disease Control and Prevention. To raise awareness about these significant concerns, Dr Emily Volk, President of the College of American Pathologists, conducted a nationwide media tour. Topics that Dr. Volk addressed included: What exactly RSV is and how it spread Why we are seeing a surge in RSV cases How someone can tell the difference between RSV, Flu, and Covid symptoms If families want to travel and be with their families, this holiday season what precautions are needed to do that safely If you want more information on testing, please visit: cdc.gov/rsv cdc.gov/flu/weekly Contact Details YourUpdateTV +1 212-736-2727 yourupdatetv@gmail.com
December 21, 2022 10:09 AM Eastern Standard Time
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News ReleaseYourUpdateTV
Unlike a food allergy, which generates an immediate response and can more easily be identified and isolated from your diet (such as a peanut allergy), food sensitivities will produce a delayed reaction, and can be from a multitude of substances. As a result, they are much harder for people to detect. It's vital to know about food sensitivities that may negatively affect your health. Recently, Dr. Wajahat Mehal, Professor of Medicine and Digestive Diseases at Yale University School of Medicine, participated in a nationwide satellite media tour to discuss food sensitivities A video accompanying this announcement is available at: https://youtu.be/f12Cqq2hwsU A recent survey from That’s it. Nutrition shows that 51% of American households are impacted by food allergies or sensitivities. Many health conditions, including being overweight, migraines, rashes, arthritis, fatigue, bloating, gastrointestinal disorders, irritable bowel syndrome (IBS), Crohn’s disease and even certain respiratory conditions and skin disorders are affected by an overlooked or misunderstood food sensitivity. Nonceliac gluten sensitivity is one such example. Researchers at Yale School of Medicine conducted a landmark study showing that patients with IBS who follow individualized diets based on an Alcat food sensitivity blood test experienced significant symptom improvement. State of the art biological testing such as the Alcat test provides a cellular-based lab analysis to evaluate over 450 food substances and additives to determine which foods may be the offenders. Based on these test results a nutritionist can help you develop an individualized eating plan to best support a patient’s health For more information, visit previmedica.com About Dr. Mehal Dr. Mehal graduated from the University of Oxford Medical Sciences Division in 1989. He works in West Haven, CT and 5 other locations and specializes in Gastroenterology. Dr. Mehal is affiliated with Yale-New Haven Hospital Saint Raphael Campus. Dr. Mehal is the Director of the Yale Fatty Liver Disease Program, Yale School of Medicine and developed an integrated NAFLD program encompassing non-invasive diagnostics, staging, nutrition, weight loss medications, HCC screening and tumor board, liver transplantation and bariatric surgery. He is also the Director of the Yale Weight Loss Program, Yale School of Medicine and helped create a new program that brings all non-surgical weight loss components into a single place and include lifestyle/dietary interventions, psychological (Mindfulness training), medications, meal replacement, and endoscopic approaches (gastric balloon). Contact Details YourUpdateTV +1 212-736-2727 yourupdatetv@gmail.com
December 21, 2022 06:09 AM Eastern Standard Time
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News ReleaseThe Chicago School of Professional Psychology
Studies show that by February, 80 percent of New Year’s resolutions have been abandoned. So how do you make sure yours are among the 20 percent that are kept longer than a couple of months? Psychologists say it’s important to focus not on the goal but on the process of change. New Year’s resolutions often fail because they encourage a goal-oriented, rather than a process-oriented approach. It’s not about achieving a single goal, it’s about developing a habit or set of habits that result in the desired goal(s). “The process of change starts with understanding that a behavior is producing negative consequences,” says Dr. Michele Nealon, Psy.D., President of The Chicago School of Professional Psychology. “Then comes the internal negotiation—evaluating the pros and cons of changing. When you decide to change, then comes preparation, and this is critical—set yourself up for success.” “Next, decide your action steps and how you plan to maintain or modify these steps over time,” she adds. “Finally, plan for falling off the wagon—and get right back on track.” According to Dr. Nealon, this process can take weeks or months, so that is another reason why New Year’s resolutions often don’t work. “It’s difficult to wake up one day and suddenly decide you will change a long-held habit or practice,” she says. “Better to give yourself some time to think over the entire process and make sure that you are committed to change." She offers five tips for increasing chances of successful change include: Make change actionable and measurable Create a plan for incremental change; taking small steps to start Challenge yourself to be accountable or find an accountability partner Be forgiving; when you inevitably fall off the wagon, get back up About The Chicago School of Professional Psychology: Integrating theory with hands-on experience, The Chicago School of Professional Psychology provides education rooted in a commitment to innovation, service, and community for thousands of diverse students across the United States and globally. Founded in 1979, the nonprofit, regionally accredited university now features campuses in iconic locations across the country (Chicago, Southern California, Washington, D.C., New Orleans, Dallas) and online. To spark positive change in the world where it matters most, The Chicago School has continued to expand its educational offerings beyond the field of psychology to offer more than 30 degrees and certificates in the professional fields of health services, education, counseling, business, and more. Through its engaged professional model of education, commitment to diversity and inclusion, and an extensive network of domestic and international professional partnerships, The Chicago School’s students receive real-world training opportunities that reflect their future careers. The Chicago School is proud to be a part of TCS Education System, a nonprofit, integrated system of colleges and universities that works collaboratively to advance student success and community impact. To learn more, visit www.thechicagoschool.edu. Contact Details Vivien Hao +1 323-893-4743 vhao@thechicagoschool.edu
December 19, 2022 09:00 AM Pacific Standard Time
News ReleaseHong Kong Baptist University
HONG KONG SAR - Media OutReach - 19 December 2022 - A research team led by Hong Kong Baptist University (HKBU) has identified a molecular target for bone anabolic therapies using a selected aptamer that serves as an inhibitor of sclerostin, a protein that prevents bone growth. The discovery offers hope for the development of an effective next-generation treatment for osteoporosis and osteogenesis imperfecta that is free of cardiovascular risk compared to the marketed antibody drug. The research findings have been published in the international academic journals Nature Communications and Theranostics. The New drug is at the pre-clinical trial development stage, and the research team plans to start clinical trials in the US and on the Mainland in 2024. Current medication increases cardiovascular risk Osteoporosis is a metabolic condition which leads to a reduction in bone density, resulting in weakened bones that are more fragile and likely to break. O steogenesis imperfecta, also known as “brittle bone disease”, is a rare congenital genetic disorder characterised by extremely fragile bones. Sclerostin has been identified as a therapeutic target for both diseases. In 2019, the US Food and Drug Administration (FDA) approved the use of the monoclonal antibody against sclerostin for the treatment of postmenopausal osteoporosis. Studies have also shown that sclerostin antibody enhances bone mass and bone strength of mice with osteogenesis imperfecta. However, as sclerostin plays a protective role in the cardiovascular system, it was seen that sclerostin antibody increased the risk of heart attacks, stroke and cardiovascular death during clinical trials. Therefore, a black box warning for potential cardiovascular risks is required by FDA. A research team led by Professor Lyu Aiping, Dr. Kennedy Y.H. Wong Endowed Professor in Chinese Medicineand Director of the Institute of Integrated Bioinformedicine and Translational Science at HKBU; Professor Zhang Ge, Director of the Law Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases at HKBU; and Dr Yu Yuanyuan, Manager of the Guangdong-Hong Kong-Macau Greater Bay Area International Research Platform for Aptamer-based Translational Medicine and Drug Discovery and Assistant Professor of the School of Chinese Medicine at HKBU, endeavoured to develop alternative drug options. “loop3” identified as a new therapeutic target Sclerostin suppresses bone formation by antagonising the “Wnt signalling pathway”. The “Wnt signalling pathway” modulates the stem cells responsible for skeletal tissue regeneration. Therefore, inhibition of sclerostin promotes bone growth. The research team discovered that a “loop3 domain” in the core region of sclerostin can be used as a molecular target to inhibit sclerostin. Through genetic studies, it was shown that deficiency of the loop3 domain can inhibit sclerostin’s antagonistic effect against the Wnt signalling pathway, but it does not affect the cardiovascular protective effect of sclerostin. The result suggests that the loop3 domain can serve as a molecular target for inhibiting sclerostin while preserving its cardiovascular protective function. The researchers then proceeded to screen aptamers that can specifically inhibit sclerostin loop3. Aptamers are single-stranded DNA or RNA molecules that can selectively bind to molecular targets such as proteins. After binding with specific proteins, aptamers may inhibit protein–protein interactions and thereby elicit certain therapeutic effects. Through a combinatorial technology, an aptamer “aptscl56” was selected as a potential sclerostin inhibitor that targets the loop3 structure. Aptamer selected as effective and safe sclerostin inhibitor The research team examined aptscl56’s therapeutic functions with osteoporotic rat models and osteogenesis imperfecta mouse models. They found that aptscl56 effectively promots bone formation. On the other hand, the application of aptscl56 does not increase the risk of developing cardiovascular diseases such as aortic aneurysms and atherosclerotic development in both models. The medical use of aptamers confers certain advantages, such as thermal stability and ease of synthesis. However, they are prone to rapid degradation and renal filtration. The research team therefore modified aptscl56 to produce an aptamer named “Apc001” with a longer half-life. The team demonstrated that Apc001 promotes bone formation, increases bone mass, improves bone microarchitecture integrity, and enhances bone mechanical properties in rats with osteoporosis and mice with osteogenesis imperfecta. Clinical trials due to start in 2024 “Searching for reliable and safe alternatives to overcome the limitations of the currently available drugs is crucial to help patients who need bone anabolic therapies. Our ongoing studies, which span from identifying molecular targets for sclerostin inhibition to aptamer drug discovery, offer hope for the development of next-generation sclerostin inhibitors in the near future,” said Professor Zhang Ge. “Our search for alternative drugs for bone anabolic therapies is a good example of tripartite collaboration between academia, industry and the government. The research work was partly conducted in collaboration with a local biotechnology company, and it was supported by the Innovation and Technology Fund. Some biotechnology companies in the Mainland were engaged in certain aspects of developmental research for the aptamer, such as toxicology tests. The collaborative efforts will continue to create more synergy and fruitful results,” said Professor Lyu Aiping. The therapeutic aptamer Apc001 was granted orphan drug designation by the FDA for the treatment of osteogenesis imperfecta in 2019. Contact Details Communication and Public Relations Office, HKBU Christina Wu hkbunews@hkbu.edu.hk
December 19, 2022 09:00 AM Eastern Standard Time
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News ReleasePatient Safety Authority
The nursing field offers huge career opportunities. But with a critical nursing shortage and new complexities for those entering the profession, how can we ensure the next generation of nurses can handle whatever might come their way? What does it take to successfully transition them from classroom into practice? These are some of the questions addressed in the December issue of PATIENT SAFETY. “We need to prepare our nurses to learn in a new way and adapt how they make decisions, even at the bedside,” says Cedar Crest College senior instructor Eileen Fruchtl, MSN. She explores issues such as simulation technology, testing for decision making, core curricula and the expanding roles of nurses in the article, Onward and Upward: The Future of Nursing Education. “Most people don’t see the complexity of what a nurse does at the bedside, what they have to have in their knowledge base to keep patients safe,” she says. “The core curriculum integrates things that didn’t even exist years ago—like informatics. We see a lot more in politics and advocacy, leadership and management, and communities.” Fruchtl explains that nurses drive the healthcare system through their work in policy making, insurance, education, and in the community. “A lot of students don’t realize the extent of the opportunities they’ll have.” Transitioning students from academia into safe practice is the subject of another article based on a study conducted by faculty at Commonwealth University, Bloomsburg Campus, University of Wisconsin-Milwaukee College of Nursing and Indiana University of Pennsylvania. Their research revealed new nurses’ challenges including lack of skill dexterity, absence of mentors, and imposter syndrome. Enhancing academic curriculum, cooperative efforts between practice nurses and faculty, and improving nurse residency programs can narrow the academic practice gap, the authors conclude. Other topics in this issue of PATIENT SAFETY include: How a peer support program improves care for all – Jefferson Health’s RISE program is a psychological first-aid, peer-support team for distressed healthcare workers and providers in the immediate wake of a stressful or traumatic workplace event. Jefferson’s program leads, John Olsen and Dr. Scott Cowan, explain the program’s genesis, its positive impact, and how it can be replicated in other institutions. An inside look to healthcare in prison – Erica Benning, Bureau of Healthcare director for the Pennsylvania Department of Corrections (PA DOC), discusses healthcare delivery for almost 40,000 incarcerated individuals: what can be done in-house, how her team handles inmates with mental illness, their COVID response, and more. PATIENT SAFETY is the peer-reviewed journal of the Patient Safety Authority. A scientific publication, PATIENT SAFETY humanizes patient harm with stories, opinion pieces, and magazine-quality design. It has a readership of more than 45,000 people in 164 countries. About PSA Established under the Medical Care Availability and Reduction of Error (MCARE) Act of 2002, the PSA, an independent state agency, collects and analyzes patient safety data to improve safety outcomes and help prevent patient harm. http://patientsafety.pa.gov/ Contact Details Bev Volpe +1 609-230-4696 bev@madisongall.com Company Website http://patientsafety.pa.gov/
December 16, 2022 12:52 PM Eastern Standard Time
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News ReleaseICode Foundation
The 6th Edition of the ICode Global Hackathon was concluded on 10th December with 800 finalists from 16+ countries participating in it. The Hackathon 2022 started with over 2 million students from 72+ countries participating in the competition, the ICode Global Hackathon has again emerged as the world’s largest coding competition for school students aged 6-16 years. Designed as a gamified, multi-level event, the 2022 edition of the hackathon started with local-level competitions across 72+ countries. The top 10% of participants at each level moved on to their respective national and then regional finals. This year's final saw 800 of the world’s best young coding minds compete for the coveted prize of ICode Global Hackathon champions. The list of countries included a wide spectrum; from developed nations like the USA, Canada, the UAE, South Korea and Singapore to emerging economies like India, South Africa, Thailand, Philippines, Egypt, Myanmar and others. We also saw strong representation from the African Continent with 14 students participating from Ghana, South Africa and Nigeria. Ami Dror, the Chairman of ICode Foundation said, “We are very proud of the efforts of all the participants including the 2 million+ students who participated at the local level of competition in their respective countries. As a platform, ICode Global Hackathon is probably the only global platform that helps students test their algorithmic intelligence and computational thinking skills on a gamified platform and benchmark themselves against their global peers.” “Our students from Australia had a blast while competing in the ICode Hackathon. Kids learned all the basics with the helpful tutorials before taking some truly mind-bending coding challenges. Parents can relax knowing that their children are learning a life skill, and children get the chance to see how they stack up against thousands of their peers around the world. We look forward to continuing our partnership with the ICode Hackathon in 2023,” said Garry Law, Director of Creator Academy. Amit Yadav, the Global Head of Partnerships at ICode Foundation said, “The ICode Global Hackathon is a truly global competition with children representing diverse learning cultures and education systems and the ICode platform acting as a strong tool for learning equity in coding education. We are proud of the fact that a large number of students from developing economies featured in the Global top 100 this year.” The ICode Foundation will launch the 7th Edition of the ICode Global hackathon on 1st March 2023 and will start accepting applications for institutional partnerships from 1st Jan 2023. About ICode Foundation It is a leading global organisation that creates and provides assessment, benchmarking, and certification platforms to students, education systems, school systems, and governments around the world; using cutting-edge gamification and AI tools. It organises the World’s Largest Coding Competition for kids - the ICode Global Hackathon. Contact Details ICode Foundation Amit Yadav - Business Head ICode Foundation +91 99107 35297 info@icode.education Company Website https://icode.org/
December 14, 2022 10:00 AM Eastern Standard Time
News ReleaseVolatus Aerospace Corp.
Volatus Aerospace Corp. (TSXV: VOL) (OTCQB: VLTTF) ("Volatus" or "the Company") is pleased to announce the expansion of its Science Experiential Aerial Research (SEAR) Program in participating school divisions throughout Manitoba thanks to a grant provided by Research Manitoba with the support of the Government of Manitoba and additional funding from industry partners. The Company’s SEAR program is designed to partner high school students with industry to research unique alternatives to solving relevant community sustainability issues. For the two projects in Manitoba, Volatus will provide drones equipped with remote sensors to gather aerial data in targeted areas and apply machine learning analytics tools to identify the possible presence of Dutch Elm disease—a significant threat to the health of their urban tree canopy—and crop disease in specific crop varieties local to the region such as canola, lentils, and wheat. “This is an exciting project on so many levels,” said Glen Lynch, CEO of Volatus Aerospace. “Not only does it represent an investment in our youth, but the result will facilitate the early detection of Dutch Elm disease, a costly, deadly disease affecting all species of elm trees allowing for early treatment. Similarly, early detection of crop disease will allow our producers to protect valuable food stocks and preserve their yield.” A minimum of 195 high school students (grades 9-12) from Manitoba School Divisions will develop important STEAM (science, technology, engineering, arts, and mathematics) skills by working with Volatus. Through a comprehensive year-long program, students will take part in almost every stage of the scientific discovery process, culminating in a “Data Collection Field Day,” which will apply the skills learned throughout the year. During the Data Collection Field Day, students will collect aerial and ground-based data samples alongside researchers from the University of Winnipeg to assess the growth and health conditions of the targeted areas. Students will be encouraged to continue with the SEAR program, where they will be exposed to increasingly more complex aspects of drone and machine learning technologies. In addition, students will have the opportunity to work towards obtaining their Transport Canada Basic or Advanced RPAS pilot certificates throughout the program. The professional training and knowledge that students obtain from the program will enable them to pursue career opportunities in STEAM as well as the drone industry, aviation and aerospace. “This program has been a personal passion since we first launched it in 2021 with Seven Oaks School Division in Winnipeg,” said Matthew Johnson, Regional Vice President, Prairies & Director, Education for Volatus Aerospace. “Through these programs we are able to engage students in the process of solving real world problems while providing them with a learning opportunity usually limited to funded university-level programs.” Leveraged funding is $1,238,283 from project partners including $500,000 in Funding provided by Research Manitoba with financial support from the Government of Manitoba, contributions from Southport Aerospace, Winnipeg Airports Authority, Roquette, Integrated Crop Management Services, and additional support from the City of Winnipeg, and Manitoba Aerospace. About Volatus Aerospace: Volatus Aerospace Corp. is a leading provider of integrated drone solutions throughout North America and growing into Latin America and globally. Volatus serves civil, public safety, and defense markets with imaging and inspection, security and surveillance, equipment sales and support, training, as well as R&D, design, and manufacturing. Through our subsidiary, Volatus Aviation, we are introducing green and innovative drone solutions to supplement and replace traditional aircraft and helicopters for long-linear inspections such as pipeline, energy, rail, and cargo services. Volatus is committed to carbon neutrality; the fostering of a safe, equitable and inclusive workplace; and responsible governance. Forward-Looking Information This news release contains statements that constitute “forward-looking information” and “forward-looking statements” within the meaning of applicable securities laws, including statements regarding the plans, intentions, beliefs, and current expectations of the Company with respect to future business activities and operating performance. Often, but not always, forward-looking information and forward-looking statements can be identified by the use of words such as “plans”, “expects”, “is expected”, “budget”, “scheduled”, “estimates”, “forecasts”, “intends”, “anticipates”, or “believes” or variations (including negative variations) of such words and phrases, or statements formed in the future tense or indicating that certain actions, events or results “may”, “could”, “would”, “might” or “will” (or other variations of the foregoing) be taken, occur, be achieved, or come to pass. Forward-looking information includes information regarding: (i) the business plans and expectations of the Company; and (ii) expectations for other economic, business, and/or competitive factors. Forward-looking information is based on currently available competitive, financial, and economic data and operating plans, strategies, or beliefs as of the date of this news release, but involve known and unknown risks, uncertainties, assumptions and other factors that may cause the actual results, performance or achievements of the Company to be materially different from any future results, performance or achievements expressed or implied by the forward-looking information. Such factors may be based on information currently available to the Company, including information obtained from third-party industry analysts and other third-party sources, and are based on management’s current expectations or beliefs. Any and all forward-looking information contained in this news release is expressly qualified by this cautionary statement. Investors are cautioned that forward-looking information is not based on historical facts but instead reflects expectations, estimates or projections concerning future results or events based on the opinions, assumptions and estimates of management considered reasonable at the date the statements are made. Forward-looking information and forward-looking statements reflect the Company’s current beliefs and is based on information currently available to it and on assumptions it believes to be not unreasonable in light of all of the circumstances. In some instances, material factors or assumptions are discussed in this news release in connection with statements containing forward-looking information. Such material factors and assumptions include, but are not limited to: the commercialization of drone flights beyond visual line of sight and potential benefits to the Company; and meeting the continued listing requirements of the TSXV. Although the Company has attempted to identify important factors that could cause actual actions, events or results to differ materially from those described in forward-looking information, there may be other factors that cause actions, events or results to differ from those anticipated, estimated or intended. The forward-looking information contained herein is made as of the date of this news release and, other than as required by law, the Company disclaims any obligation to update any forward-looking information, whether as a result of new information, future events or results or otherwise. There can be no assurance that forward-looking information will prove to be accurate, as actual results and future events could differ materially from those anticipated in such statements. Accordingly, readers should not place undue reliance on forward-looking information.Neither the TSXV nor its Regulation Services Provider (as that term is defined in the policies of the TSXV) accepts responsibility for the adequacy or accuracy of this news release. Source: Volatus Aerospace Corp. TSXV: VOL Contact Details Abhinav Singhvi +1 514-447-7986 abhinav.singhvi@volatusaerospace.com Company Website https://volatusaerospace.com
December 13, 2022 04:59 PM Eastern Standard Time
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