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New Research Finds that People Who Use Cannabis Early in Pregnancy Are At Increased Risk of Poor Pregnancy Outcomes

Society for Maternal-Fetal Medicine

As more states legalize marijuana for recreational use, researchers are looking into the potential health effects of cannabis use during pregnancy. In a new study to be presented today at the Society for Maternal-Fetal Medicine’s (SMFM) annual meeting, The Pregnancy Meeting™ — and published in the American Journal of Obstetrics & Gynecology — researchers will unveil findings that suggest that using cannabis in the first six to 14 weeks of pregnancy is associated with poor pregnancy outcomes that are closely related to the function of the placenta. The placenta plays an important role during pregnancy, including providing an infant with oxygen and nutrients, removing harmful waste and carbon dioxide, and producing hormones that help a baby grow. Medicine, drugs, alcohol and nicotine can transfer from a pregnant person’s bloodstream to their baby through the placenta. Researchers analyzed urine samples collected during the Nulliparous Mothers-to-Be (nuMoM2b) study, a large, diverse multicenter cohort of pregnant people. Of the 10,038 nuMoM2b participants, researchers included data from 9,257 pregnant people in their first trimester of pregnancy. After doing a drug screen for marijuana, researchers discovered that 540 (5.8 percent) tested positive for marijuana, meaning those individuals most likely used cannabis in the first six to 14 weeks of their pregnancy. The study found that using cannabis early in pregnancy is associated with adverse pregnancy outcomes related to the placenta, such as poor fetal growth, stillbirth, and an increased risk of developing high blood pressure during pregnancy. “We wanted to look specifically at cannabis use early in pregnancy because that’s when the placenta is forming, and a lot of information we currently have indicates that cannabis use does affect the placenta,” says the study’s lead author Torri D. Metz, MD, MS, a maternal-fetal medicine subspecialist and associate professor of obstetrics and gynecology at the University of Utah Health in Salt Lake City. “With recreational marijuana use becoming legal in more states, we need better data because patients are interested in understanding the risk of cannabis use in pregnancy so they can make an informed decision.” The next step, say researchers, is to look at ongoing cannabis use during pregnancy and whether “the window of exposure” matters. To view the presentation of this abstract or other Pregnancy Meeting™ abstracts and events, visit the SMFM website or contact Karen Addis at karen@addispr.com or 301-787-2394. ### About the Society for Maternal-Fetal Medicine The Society for Maternal-Fetal Medicine (SMFM), founded in 1977, is the medical professional society for maternal-fetal medicine subspecialists, who are obstetricians with additional training in high-risk pregnancies. SMFM represents more than 5,500 members who care for high-risk pregnant people and provides education, promotes research, and engages in advocacy to advance optimal and equitable perinatal outcomes for all people who desire and experience pregnancy. For more information, visit SMFM.org and connect with the organization on Facebook and Twitter. For the latest 2023 Annual Meeting news and updates, follow the hashtag #smfm23. Contact Details Addis Communications Karen Addis +1 301-787-2394 karen@addispr.com Society for Maternal-Fetal Medicine Kerri Wade +1 202-236-1780 kwade@smfm.org Company Website https://www.smfm.org/

February 09, 2023 08:36 AM Pacific Standard Time

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ImmuPharma expects new Lupozor study to begin in H2 2023

ImmuPharma PLC

ImmuPharma PLC (AIM:IMM, OTC:IMMPF) chief executive Tim McCarthy spoke to Thomas Warner at Proactive's London studio after announcing that its partner Avion Pharmaceuticals is to launch an adaptive phase II/III clinical study on Lupuzor, the former’s discovery and putative treatment for systemic lupus erythematosus (SLE). McCarthy reveals the reasons for choosing the particular type of study and explains what else investors can expect from ImmuPharma during 2023. Contact Details Proactive UK Ltd Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

February 09, 2023 06:07 AM Eastern Standard Time

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AMERICAN DIVERSIFIED HOLDINGS CORP (OTC: "ADHC") TO EXHIBIT ROLLSCHOICE ™ ADHESIVE PENS AT CHAMPS TRADE SHOW

American Diversified Holdings Corp.

McapMediaWire -- American Diversified Holdings Corporation (OTC: ADHC ) announced today that the Company has been invited to attend the CHAMPS TRADE SHOW by Green Globe International (OTC: GGII ) and Hempacco (NASDAQ: HPCO ). At the show, Hempacco management team will be formally launching its New Partnership with Hip Hop Icon Snoop Dogg Brands. HPDG, Inc. a newly formed California LLC, co-owned by Snoop Dogg and Hempacco will develop, manufacture and market a line of smokable hemp products including blunts, papers, vapes and edibles. Click here for more information on the Hempacco/Snoop Dogg Partnership "ADHC has presented the Rolls Choice™ adhesive pen to the Hempacco Product Development team and has been invited to display the product at the CHAMP show. We believe the Rolls Choice™ Pen could be a perfect fit to the Hempacco/Snoop Dogg partnership. We anticipate showing the product to leading distributors, retails and marketers in the cannabis arena," commented ADHC Management. "This is a tremendous opportunity for Rolls Choice™ and ADHC to be introduced to leaders in the Cannabis sector, The extensive platform of GREEN GLOBE, HEMPACCO and SNOOP DOGG could be a game changer for our brand," commented Allan Staines, of ADHC/Rolls Choice™. ABOUT Champs Trade Shows – CHAMPS TRADE SHOWS is widely recognized as the largest and most trusted counter-culture trade show in the world. Since 1999, CHAMPS has hosted the premier exhibitors in the industry and draws buyers in the thousands from all over the world to attend. Please join our network of friends and be part of our ever-growing family by signing up for our newsletter or registering as a buyer or exhibitor. ADHC has recently agreed to acquire Rolls Choice™ as a wholly owned subsidiary and provide additional funding to Rolls Choice™for inventory and marketing. Shareholders, customers and other interested parties can find product offerings by searching AMAZON under these UPC codes B0B1BTNW4Q and B0B2R3D2TS or clicking this link: Amazon.com: RollsChoice Adhesive Pen (25, 1ml): Office Products Rolls Choice™has a pending trademark with the USPTO under the application number 972978083. SOCIAL MEDIA STRATEGY: Rolls Choice™ has over 80,000 social media followers which will be introduced to ADHC social media platforms on Twitter, Instagram, Facebook, and TikTok. This relationship will establish a very strong presence, providing brand awareness to potential customers and shareholders as the Universal Wellness/Rolls Choice™ business relationship develops and revenues grow. About Rolls Choice™: Website: www.Rollsschoiceadhesive.com Email: rollschoicerepresentative619@gmail.com Twitter: https://www.twitter.com/rollschoice Instagram: https://www.instagram/rollschoicadhesivepen Tel: 619-678-6657 Rolls Choice™ is a Southern California based manufacturer, distributer and ecommerce company selling an all-natural Adhesive Glue and application device. The Pens come in 1 ml, 2 ml and 100 pen packs. Rolls Choice™ has significant brand awareness in the cannabis industry and boasts over 80,000 followers on Twitter and Instagram. Over 12,000 adhesive pens have been manufactured and sold. The adhesive is made of Food Grade Premium ingredients. Rolls Choice Adhesive Pen is Flavorless, Colorless, Tasteless and Stainless. It is used to seal cannabis and tobacco rolled products including blunts, joints, cigars and hand rolled cigarettes in a sterile manner allowing for long lasting adhesive qualities. The proprietary brush tip pen is recommended for precision. RC sells direct to smoke shops, dispensaries and direct to consumers through its e-commerce site. Through the companies multi year history sales over 12,000 adhesive pens and been manufactured and sold by Rolls Choice. see (USPTO ROLLS CHOICE 97278083). In addition to the adhesive pen, RC has numerous other cannabis related products being developed that will be introduced as a result of this Acquisition agreement. About ADHC: American Diversified Holdings Corporation (OTC: ADHC) is a publicly traded holding company trading under the ticker symbol (OTC: ADHC). ADHC is currently developing three web-based businesses. http://www.UniversalWellnessHC.com ("UWHC") UWHC is a wellness and lifestyle e-commerce site focused on providing innovative products, news, and the latest healthcare developments. Investor Contact: Ernest Remo Chairman/CEO EMAIL: ernestremo@san.rr.com Tel: 858-259-4534 TWITTER: @ADHCManagement. This Twitter page is the only official Twitter page for ADHC. Information contained herein includes forward-looking statements. These statements relate to future events or future financial performance, involving known and unknown risks and uncertainties that may cause our actual results to be materially different from the performance or achievements expressed. You should not place undue reliance on these statements since they involve known and unknown risks, in some cases, beyond our control. Contact Details American Diversified Holdings Corporation Ernest Remo +1 858-259-4534 ernestremo@san.rr.com Company Website https://rollschoiceadhesive.com/

February 09, 2023 06:00 AM Eastern Standard Time

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Feedback PLC reports "very strong" interims

Feedback PLC

Feedback PLC (AIM:FDBK) CEO Dr Tom Oakley speaks to Proactive's Thomas Warner after publishing interim results for the specialist medical imaging technology company that he describes as "very strong." Oakley reveals the opportunity that his focus has been on during the post-period and looks ahead to what investors can expect from the business during the coming months. Contact Details Proactive UK Ltd Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

February 09, 2023 05:52 AM Eastern Standard Time

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Proactive research analyst says Tiziana Life Sciences "moving forward quite nicely"

Tiziana Life Sciences PLC

Proactive research analyst Robin Davison speaks to Thomas Warner after publishing a 2023 Clinical Outlook for clinical stage biotechnology company Tiziana Life Sciences Ltd (NASDAQ:TLSA). He gives his take on what the market can expect from the business this year, saying that it is now "moving forward quite nicely." Contact Details Proactive UK Ltd Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

February 09, 2023 05:24 AM Eastern Standard Time

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hVIVO Asian growth strategy bearing fruit with second 2023 contract win

hVIVO PLC

hVIVO PLC (AIM:HVO) Director of Business Development for Europe and Asia Egle Pavyde speaks to Proactive's Thomas Warner after announcing the company's second contract win of the year in the Asia-Pacific region. Pavide reveals more details about the contract and says she is delighted with the progress made in exploring new opportunities in what she calls a rapidly growing market. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

February 09, 2023 03:00 AM Eastern Standard Time

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February is Pet Dental Health Month

YourUpdateTV

Dental disease affects 80% of adult dogs and 96% of senior dogs[1], but new data from WHIMZEES ® by Wellness ® finds that very few Gen Z and Millennial pet parents are brushing their dog’s teeth daily, and less than one-half (44%) could list the signs of disease to their vet.[2] With February being Pet Dental Health Month, it is the perfect opportunity to start a proper doggy dental routine. Recently, Dr. Danielle Bernal, veterinarian with WHIMZEES ® by Wellness ®, participated in a nationwide satellite media tour to discuss pet dental health and what pet parents can do to establish a healthy routine. A video accompanying this announcement is available at: https://youtu.be/cI_Hd6OfAIw Ideally, pet parents should be thinking about their dog’s teeth the same way they do their own. When it comes to at-home care, daily brushing of a dog’s teeth with a toothbrush and special canine toothpaste works, but pet parents often face toothbrush troubles.In fact, WHIMZEES by Wellness found that Gen Z and Millennial pet parents’ dogs have given side eye (58%) or run away (41%) at the sight of one. “If you are struggling with brushing your dog’s teeth consistently, incorporating a daily dental chew can be an excellent resource to help maintain your dog’s dental care and keep those tails wagging,” said Dr. Danielle Bernal. “In addition to daily dental care, it’s important to recognize the signs of periodontal disease, such as discoloration, broken or loose teeth, super stinky breath, reduced appetite and inflamed gums. By incorporating a daily dental chew like WHIMZEES by Wellness, pet parents can ensure they’re treating their dogs well and give them healthy smiles to live happier and healthier lives together.” WHIMZEES by Wellness all-natural dental treats allows pet parents to treat dogs well by combining the joy of treats with health benefits of supporting healthy teeth and gums. By giving just one WHIMZEES treat a day to fight bacteria that resurfaces daily, dogs get twice the cleaning power because WHIMZEES last three times longer to provide more cleaning time.[3] They are thoughtfully engineered with grooves and ridges to provide dogs with both chomping and cleaning, making WHIMZEES the treat that treats them well. WHIMZEES ® by Wellness ® dental treats are conveniently available at pet specialty retailers, national retailers and online. To learn more about WHIMZEES by Wellness and find them near you, visit https://www.whimzees.com/. About Dr. Danielle Bernal Danielle Bernal, D.V.M., has over a decade of experience in veterinary medicine, specializing in animal nutrition. In her role as on-staff veterinarian at Wellness Pet Company, maker of premium natural food and treats for dogs and cats, including WHIMZEES ® by Wellness ®, she educates pet parents and retailers alike on the importance of natural ingredients like wholesome meats and nutrient-rich superfoods and the highest quality standards. She passionately believes that proper nutrition helps pets lead happier, healthier lives and she shares that message with pet parents [1] Ozy, Sweeney, Dog Owners Have a New Obsession: Dental Health for Their Pets, March 2019 [2] Conducted in December 2022, Pollfish collected data via an online survey from a random sampling of 1,000 Gen Z and Millennial (ages 18-41) dog parents identified as demographically representative of the U.S. population. [3] Based on studies of comparable products conducted by an independent kennel Contact Details YourUpdateTV +1 212-736-2727 yourupdatetv@gmail.com

February 08, 2023 01:46 PM Eastern Standard Time

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Empower Clinics agrees to partnership to launch US clinical trial management service

Empower Clinics Inc.

Empower Clinics CEO Steven McAuley joined Proactive's Steve Darling to share news the company has signed a Letter of Intent with Las Vegas-based nuclear medicine specialist Dr Bharat Mocherla to create and operate a Dallas-based Site Management Organization. McAuley told Proactive the end goal is to evolve this into a Contract Research Organization. The sector is booming with revenue in the neighborhood of $76 billion estimated for 2023. The partnership will give Empower the chance to work with industry, patients, community doctors and researchers in North America to provide clinical trial management services for the pharmaceutical, biotechnology and medical device industries. Contact Details Proactive Investors Canada +1 604-688-8158 na-editorial@proactiveinvestors.com Company Website https://www.proactiveinvestors.ca/

February 08, 2023 01:27 PM Eastern Standard Time

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Coverage at the Speed of Life: Guarantee Trust Life Insurance Company & AmeriLife Unveil Turbo Term Life

AmeriLife

Continuing their approach to innovative product design and delivery, Guarantee Trust Life Insurance Company (“GTL”) and AmeriLife Group, LLC (“AmeriLife”) announced today the launch of Turbo Term Instant Issue Life Insurance, a revolutionary new level term life product engineered to deliver clients fully customized benefits and policy lengths to match their unique needs. “Guarantee Trust is excited to partner with AmeriLife in developing and bringing to the consumer the most dynamic term product offering in the marketplace, said Richard S. Holson III, GTL’s chairman of the board, president and CEO. “We are proud to be aligned with the great marketing organization that is AmeriLife.” With GTL’s state-of-the-art underwriting platform powered by hr | ReFlex, Hannover Re’s automated underwriting system, long application processing is a thing of the past. With a fully digital application process — and no medical exams — agents can deliver their clients an affordable policy instantly with customizable coverage, flexible benefits, a variety of level term lengths, and coverage between $100,000 and $1,000,000. For agents, Turbo Term lets them stay in the driver’s seat by owning the business they write, offering advance commissions at all levels and supporting full hierarchy, a wholly unique value proposition versus any other product on the market. “Turbo Term was built for agent distribution. No long apps. No uncomfortable medical exams. Just a fully digital application process and great, affordable, and customizable coverage to deliver the financial stability client needs – fast,” said David Paul, AmeriLife’s national sales director of Simplified Issue Life. “We’re thrilled to partner with GTL on yet another innovative product that will deliver value to the market and supercharge agent sales.” “Time and again, GTL has proven to be a valuable partner in designing products and solutions with the modern agent—and modern consumer—in mind,” added Pat Fleming, AmeriLife’s executive vice president of Product Innovation and corporate actuary. “Turbo Term will undoubtedly prove to be a great addition to AmeriLife’s portfolio of holistic solutions, and we’re excited for the opportunities it will open up for our marketers and their agents.” Turbo Term Instant Issue Life Insurance is currently available in all states except California and New York. For more information, contact your AmeriLife-affiliated marketer or independent marketing organization (IMO), or visit www.turboterm.com. Attributions and Disclaimers with Respect to Guarantee Trust Life Insurance Company Turbo Term, Individual Level Term Life Insurance, is issued on Policy Form Series ICC21-21TL, and Rider Form Series ICC21-R21ADD, ICC21-R21ADB, ICC21-R1CHILD, and ICC21-21WP by Guarantee Trust Life Insurance Company (GTL), Glenview, IL. This product’s availability, features, riders and terms under which coverage may be continued in-force or discontinued vary by state. Certain exclusions and limitations apply. For cost and complete details of coverage, please contact us or your agent. GAD18.28-22 ### About Guarantee Trust Life Insurance Company Founded in 1936, Guarantee Trust Life Insurance Company (GTL) has a proud history of providing superior insurance products and best-in-class customer service to individuals and families. Through a competitive portfolio of value-driven health, accident, life and special risk insurance products, the company offers an attractive and trusted value proposition to its policyholders and distributors while encouraging and supporting personal growth and civic involvement from its employees. For more information, visit GTLIC.com. About Hannover Re Hannover Re, with gross premium of more than EUR 33 billion, is the third-largest reinsurer in the world. It transacts all lines of property & casualty and life & health reinsurance and is present on all continents with more than 3,000 staff. Established in 1966, the Hannover Re Group today has a network of more than 170 subsidiaries, branches and representative offices worldwide. The rating agencies most relevant to the insurance industry have awarded Hannover Re outstanding insurer financial strength ratings: Standard & Poor's AA- "Very Strong" and A.M. Best A+ "Superior". For more information, please visit www.hannover-re.com. About AmeriLife AmeriLife’s strength is its mission: to provide insurance and retirement solutions to help people live longer, healthier lives. In doing so, AmeriLife has become recognized as the leader in developing, marketing, and distributing life and health insurance, annuities and retirement planning solutions to enhance the lives of pre-retirees and retirees across the United States. For more than 50 years, AmeriLife has partnered with top insurance carriers to provide value and quality to customers served through a distribution network of over 300,000 insurance agents and advisors and more than 100 marketing organizations and insurance agency locations nationwide. For more information, visit AmeriLife.com, and follow AmeriLife on Facebook and LinkedIn. Contact Details AmeriLife Jeff Maldonado +1 321-297-1112 jmaldonado@amerilife.com Guarantee Trust Life Insurance Company Carl Leader +1 847-904-5455 cleader@gltic.com Company Website https://amerilife.com/

February 08, 2023 10:00 AM Eastern Standard Time

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