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ThreatModeler Software, Inc Wins Two Categories by Global Infosec Awards for 2021

ThreatModeler Software, Inc.

ThreatModeler Software, Inc is proud to announce that it has won the following two categories from Cyber Defense Magazine, the industry's leading electronic information security magazine exclusively for RSA Conferences: Most Innovative in Cloud Security Most Innovative in Threat Modeling The 9th annual Global InfoSec Awards were announced during the opening of the RSA Conference on May 17, 2021. We have been selected by CISSP, FMDHS, CEH, certified security professionals based on their independent reviews of the products/services. Innovation is the driving force here at Threatmodeler and believe this is what sets us apart to be the leader in our industry category. “We are very excited to see continuing recognition for our automated threat modeling platform and the innovation we bring to cyber security”, said Archie Agarwal, Founder and CEO of ThreatModeler Software, Inc. “We’re honored to be selected by a panel of expert judges around the globe from over 3,000 companies”. “These winners are the most innovative, forward thinking and proactive cyber security companies and service providers on the planet who are working to bring tomorrow’s cybersecurity solutions to market, today,” said Gary S. Miliefsky, Publisher of Cyber Defense Magazine. About Cyber Defense Magazine Infosec Awards This is Cyber Defense Magazine's ninth year of delivering and honoring the most innovative and valuable innovator for any startup, early-stage, later-stage, or public companies in the information security space who have a unique and compelling value proposition for their product or service. Learn more at https://cyberdefenseawards.com/ About ThreatModeler Software, Inc. ThreatModeler is an automated platform that provides a sustainable, self-service threat modeling practice for applications and infrastructure that evolves as your infrastructure grows. ThreatModeler encourages collaboration through its simple process flow diagram-based functionality that's easy to use in the creation of threat models that identify, prioritize and mitigate threats, while communicating them broadly. ThreatModeler integrates with JIRA, Jenkins, and Azure Boards and Pipelines, with bidirectional web services API also unifying stakeholders in collaboration. Teams are empowered to code fearlessly and deliver new products with security built-in as early as the design phase, which is based on global security and compliance standards. Click here to schedule a live demo with a threat modeling expert. Contact Details ThreatModeler Software, Inc Sarah Chan +1 201-266-0510 marketing@threatmodeler.com Company Website https://threatmodeler.com/

May 18, 2021 11:00 AM Eastern Daylight Time

COMCAST EQUIPS 10 COMMUNITY CENTERS AS WIFI-CONNECTED “LIFT ZONES” ACROSS SOUTHERN COLORADO

Comcast Colorado

As part of its ongoing commitment to help connect low-income families to the Internet so they can fully participate in educational opportunities and the digital economy, Comcast today announced the activation of 10 locations across Colorado Springs and Pueblo as WiFi-connected “Lift Zones.” Working with its network of nonprofit partners in the Southern Colorado region, Comcast is providing robust WiFi coverage in safe spaces to help low-income students and individuals get online, access critical resources, participate in digital literacy and workforce development trainings, and support their education during the school year and into the summer months for continuous learning. "We are grateful to Comcast for providing these Lift Zones at service providers across our city,” said Mayor John Suthers, City of Colorado Springs. “Internet connectivity has been a vital part of the continued functioning of our economy and our schools, and it’s important that we remove any obstacles that could keep people from working or learning during these unprecedented times.” "The pandemic underscored how critical a reliable internet connection is for Pueblo students and individuals,” said Mayor Nick Gradisar, City of Pueblo. "The Comcast Lift Zones being installed at community centers across the city are a welcome addition to our community, providing much-needed connectivity.” Southern Colorado organizations working with Comcast to establish Lift Zones in their respective facilities include: Colorado Springs • Boys & Girls Clubs of the Pikes Peak Region • E.A. Tutt Club • El Pomar Club • YMCA • Southeast Family • Garden Ranch Family • Salvation Army • Red Shield • Mt. Carmel Veterans Service Center Pueblo • Boys & Girls Clubs of Pueblo County • Senior Resource Development Agency (SRDA) • Sprague Clubhouse • Pueblo YMCA • Southern Colorado Youth Development “Comcast has long been a steadfast partner to Mt. Carmel Veterans Service Center as we team to support our military community,” said Robert “Bob” McLaughlin, Chief Operating Officer, Mt. Carmel Veterans Service Center. “COVID-19 forced us to expand our virtual service delivery model and Comcast has once again come along side of us to offer a helping hand to enhance the connectivity of our clients. A sincere thank you to these tremendous teammates.” "The Comcast Lift Zone allowed our members to fully participate in their virtual classroom experience, which was not the case prior the Lift Zone installation due to the lack of internet speed with so many members utilizing the WiFi at the club at the same time,” said Cheryl Martinez, Boys & Girls Clubs of Pueblo County Teen Director. These Lift Zones will feature free WiFi provided by Comcast, which allows students and adults to work on laptops simultaneously so they can successfully participate in the digital economy. This initiative provides free connectivity inside partner community centers for the next three years. “Access to the Internet is a critical component of digital equity, especially as we head into the summer months,” said Amy Lynch, Sr. Vice President Comcast Mountain West Region. “Reliable connectivity offered in a safe, clean space for students is a year-round necessity to combat summer learning loss. Consistent connectivity and locations for adults to get online, search for jobs, access healthcare information and adult education is key for all individuals in our communities to succeeded in an increasingly digital world.” Lift Zones sites are also being installed in communities throughout the state and Comcast is currently accepting nominations for potential Lift Zone sites. Visit Colorado.Comcast.com/Lift-Zones to nominate an organization and see the full list of current locations. In addition, the company is providing free access to hundreds of hours of digital skills content to help families and site coordinators navigate online learning. Lift Zone sites complement Comcast’s Internet Essentials program, which has connected more than more than 82,000 low-income Southern Coloradans and more than 480,000 Coloradans across the state to the internet at home. Today’s announcement also comes on the heels of Comcast’s recent $1 billion commitment over the next 10 years to help further close the digital divide and give even more low-income students and families the tools and resources they need to succeed in a digital world. About Comcast Corporation Comcast Corporation (Nasdaq: CMCSA) is a global media and technology company that connects people to moments that matter. We are principally focused on broadband, aggregation, and streaming with over 56 million customer relationships across the United States and Europe. We deliver broadband, wireless, and video through our Xfinity, Comcast Business, and Sky brands; create, distribute, and stream leading entertainment, sports, and news through Universal Filmed Entertainment Group, Universal Studio Group, Sky Studios, the NBC and Telemundo broadcast networks, multiple cable networks, Peacock, NBCUniversal News Group, NBC Sports, Sky News, and Sky Sports; and provide memorable experiences at Universal Parks and Resorts in the United States and Asia. Visit www.comcastcorporation.com for more information. Contact Details Comcast Leslie Oliver +1 303-810-6326 leslie_oliver@comcast.com Company Website https://colorado.comcast.com/

May 18, 2021 08:30 AM Mountain Daylight Time

Lack Of Long-Term Care Planning Forces Retirees To The Poverty Level For Assistance by Jennifer Lang Financial Services

Jennifer Lang Financial Services, LLC

Contact Details Jennifer Lang Financial Services, LLC. Jennifer Lang +1 877-487-8926 mail@jenniferlangfinancialservices.com Company Website https://www.jenniferlangfinancialservices.com

May 18, 2021 10:05 AM Eastern Daylight Time

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TRUST SCIENCE PLEDGE CALLS FOR PUBLIC TO ENGAGE IN SCIENTIFIC LITERACY

International Day of Light Steering Committee

After a year in which scientific breakthroughs are helping countries return to a sense of normality, a new pledge offers the general public a path to draw attention to the importance of scientific literacy. The Trust Science pledge, a worldwide campaign to promote support for the scientific process and acknowledge the many benefits of science for society is a first step to recognizing the vital role science plays in improving quality of life and combatting scientific misinformation. Scientific literacy, or the understanding of science, its methodology, observations and theories, starts with appreciating the wonder and advancements of science. One current example is the progress made with vaccines, but the past year has seen many other scientific developments, specifically in light science. These include advances in high-speed communications enabling families to stay connected through videoconferencing, faster access to online media content and breakthroughs in astronomy and planetary exploration such as NASA’s Perseverance Rover landing on Mars in February. With the rise of disinformation, declaring support for the scientific process provides a concrete way to stand up for science and the benefits it brings to society. The pledge, launched in celebration of the UNESCO International Day of Light on 16 May, aims to promote support for the scientific process and to acknowledge the many benefits of science for society. Nobel and Breakthrough laureates, scientific leaders, CEOs and everyday citizens worldwide have signed the pledge, taking a significant step in building scientific literacy and trust in the scientific method. “We all share responsibility for seeking out trustworthy scientific information,” said Dr. Jess Wade, a physicist working in the Department of Materials at Imperial College London. “Before sharing information about a scientific claim, we can check the source of claims, research the credibility of the author and double-check the facts with fact-checking organizations.” The pledge complements other strategies for identifying fact from fiction. A first step in achieving scientific literacy is the careful questioning of any statement that is positioned as a scientific fact. Below are three ways the general public can check the validity of something they may have read, heard or seen online as a fact: 1. Embrace initial skepticism and check the source of the claims. 2. Watch out for rhetoric. A credible author will cite facts and sources and the results of scientific research rather than “science” itself. 3. Double-check the facts with fact-checking organizations. The Trust Science campaign is organized by the IEEE Photonics Society, SPIE, the international society for optics and photonics, and The Optical Society (OSA), together with the International Day of Light Steering Committee. To sign the pledge and to learn more, please go to https://www.trust-science.org Contacts For questions about how you can engage with the campaign, please contact: info@trust-science.org For media inquiries, please contact: pr@trust-science.org Social media: please share using #TrustScience and #LightDay2021 Social media links: Facebook; Instagram; Twitter About the International Day of Light The International Day of Light (IDL) is a worldwide initiative that provides an annual focal point for the continued appreciation of light and the role it plays in science, culture and art, education and sustainable development, and in fields as diverse as medicine, communications and energy. The International Day of Light is administered from the International Basic Science Programme (IBSP) of UNESCO by a Steering Committee that includes representatives from a broad range of international partners: the American Institute of Physics (AIP), the American Physical Society (APS), Bosca, the China International Optoelectronic Exhibition (CIOE), Chinese Optical Society (COS), the European Centres for Outreach in Photonics (ECOP), the European Photonics Industry Consortium (EPIC), the European Physical Society (EPS), the Illuminating Engineering Society (IES), the International Centre for Theoretical Physics (ICTP), the IEEE Photonics Society (IPS), the International Commission on Illumination (CIE), lightsources.org - the international network of accelerator based light sources, Light: Science and Applications, The Optical Society (OSA), Tampere University, SPIE, the International Society for Optics and Photonics, SESAME, Signify, Tampere University, Thorlabs, Transitions, the Université de Franche-Comté and Velux. For information about the International Day of Light, please visit www.lightday.org Contacts for IDL: John Dudley and Joseph Niemela 2021 Steering Committee Chairs Email: contact@lightday.org Bethany Downer 2021 Communications Coordinator Email: contact@lightday.org Media Contact for Trust Science: pr@trust-science.org About IEEE Photonics Society The IEEE Photonics Society is the professional home for a global network of scientists, engineers and allied professionals who advance laser, optoelectronics, and photonics technology. As a technical society representing the IEEE, it is a vital part of the world’s largest technical professional organization of more than 400,000 members dedicated to advancing technology for the benefit of humanity. Through its highly cited publications, conferences, technology standards, educational activities, and humanitarian initiatives, the IEEE Photonics Society provides its members in more than 160 countries the opportunity to grow professionally and stay on the forefront of transformational breakthroughs in photonics. PhotonicsSociety.org About SPIE SPIE, the international society for optics and photonics, was founded in 1955 to advance light-based technologies. Serving more than 255,000 constituents from 183 countries, the not-for-profit society advances emerging technologies through interdisciplinary information exchange, continuing education, publications, patent precedent, and career and professional growth. SPIE annually organizes and sponsors approximately 25 major technical forums, exhibitions, and education programs in North America, Europe, Asia, and the South Pacific. In 2020, SPIE provided more than $5 million in support of education and outreach programs. www.spie.org About The Optical Society Founded in 1916, The Optical Society (OSA) is the leading professional organization for scientists, engineers, students and business leaders in light science and technology. The society serves over 432,000 customers and 22,000 members from more than 100 countries who fuel discoveries, shape real-life applications and accelerate achievements in the field. OSA provides quality research, inspired interactions and dedicated resources for its extensive global network of optics and photonics experts through world-renowned publications. For more information, visit osa.org. Contact Details pr@trust-science.org +1 703-907-0010 pr@trust-science.org Company Website https://www.trust-science.org

May 18, 2021 09:03 AM Eastern Daylight Time

Minuteman Press Franchise in Richmond, Kentucky Adapts and Grows During Pandemic as Essential Local Business

Minuteman Press International Inc

Pete Cummings and Chuck Bentley have owned their Minuteman Press printing and marketing franchise in Richmond since May 2014. While the COVID-19 pandemic was certainly the biggest challenge for people and local businesses everywhere, Pete and Chuck managed to remain open as an essential business, adapt their products and services to what local businesses needed during the pandemic, and position themselves for sales growth both during and after the pandemic as a result of their hard work. Pete says, “At the outset of the pandemic we were as alarmed as anyone else over not only what this could do to our business but our community and even the country as a whole. The prospect of slogging through months of economic slowdowns did cause us some anxiety in the beginning. However, we remained optimistic and determined to take advantage of any unique opportunities that the pandemic presented to those of us in the print world.” He continues, “It quickly became apparent that those businesses allowed to remain open would need COVID-related printing and signs in order to both safely assist customers as well as stay in compliance with state and local ordinances. We discovered that some organizations had been allotted grant money from the Federal Government to help with pandemic-related safety requirements. We honed in on those agencies to let them know we were open as essential business and local to them. They responded well to our outreach efforts and we ended up doing a considerable volume of business printing floor decals, signs, logo-imprinted face masks, and other safety-related products. Almost every business that chose to remain open had similar pandemic-related printing needs and we wanted to do everything possible, especially for our local small businesses, to provide them everything we could to help them navigate these unchartered waters.” “We primarily grew our business in 2020 through the expanded offering of signage, floor decals, posters, direct mail, and other essential printed items. We are anticipating that 2021 will see continued growth as more and more local businesses reopen and come back online.” -Pete Cummings, co-owner, Minuteman Press franchise, Richmond, Kentucky Supporting Local Businesses During and After the Pandemic Over the past year, Minuteman Press in Richmond has continued to reach out to local businesses as they reopen. Pete says, “We’ve seen a positive response from local business owners. Many of them seem as glad to see that we are still operating and succeeding as we are trying to help them achieve their own successes through these challenging times. I think in some ways we have had a galvanizing effect for local businesses as we are all in this together. It’s that ‘can-do spirit’ that can really lift others up and we are thankful to be a part of it.” As more restrictions continue to be lifted and other local businesses reopen and recover, Pete and Chuck are ready to help them with custom printing products and marketing services. Pete says, “Because we have stayed open the entire time, Minuteman Press has the experience of helping all different types of businesses at all different phases of the pandemic. We have proven to be a valuable partner and we are excited to provide our business community with as many resources as possible to enhance their marketing and sales efforts.” Pete continues, “Now that the tide is turning on the pandemic, we are encouraging clients to resume their direct marketing efforts. As conferences and events resume, we are promoting all of our capabilities including imprinted table throws, retractable banners, trade show displays, conference-related signage, and promotional products.” Direct mail was another key area of growth that Minuteman Press in Richmond experienced during the pandemic. Pete is excited about the future prospects of direct mail as well. He says, “Surviving and flourishing during the past year has required some adaptation. Last year, direct marketing became very challenging with social distancing becoming the norm. To continue growing we looked to direct mailings as an additional revenue stream. Based on the success we saw from these efforts, we have decided to fully embrace direct mail. We would certainly encourage other businesses to utilize direct mailings as a way to ‘connect’ with potential customers as they ramp up and reopen.” “ Contrary to what some would have one believe, printing is not dead. The increased demand for direct mailings can partly be explained by the ‘contact-free’ environment of the pandemic era. With that said, I believe it also underscores how printed advertising campaigns, when utilized effectively, can yield significant results for our customers. We have also diversified our offerings with signs, promotional items, and apparel. This provides our customers with the convenience of getting everything done under one roof through someone they trust will give them the level of service and quality they expect. So, the printing industry has evolved but those who evolve with the industry will see continued success.” -Pete Cummings Meet the People Behind the Business As Pete and Chuck celebrate seven years in business this month, they reflect on their journey as well as their experiences as Minuteman Press franchise owners. One interesting thing to note is that Pete and Chuck come from two very different backgrounds and did not have any printing experience until joining the Minuteman Press family. Pete explains, “I worked at a bank for roughly ten years after graduating from college and then owned/operated an outpatient pediatric rehabilitation center, offering Speech Therapy and Occupational Therapy to children. We were out of our home state of Kentucky at this time and once we had children we decided to return home. The same opportunities did not exist to operate a rehab center but I had small business ownership in my blood at that point and was actively looking for a good opportunity.” He continues, “Chuck was a school teacher for ten years and he was growing restless. He began looking for a business opportunity that would allow for more financial freedom for his family. He mentioned this to his uncle, Garry Conley, who just so happened to own a Minuteman Press franchise in London, Kentucky along with Chuck’s Aunt, Amy Conley. We sat down with Garry and he did a pretty good job explaining the benefits. It was evident he was running a profitable operation so we listened intently and after meeting with our Regional Vice President Gary Nowak, we decided to take the plunge.” “We opened in 2014 with zero customers and have seen steady growth every year since. Our rate of jobs quoted to jobs earned is very strong. We built the business, especially in the early years, heavily using direct marketing along with the Minuteman Press Internet Marketing program. Sometimes asking people for the opportunity to earn their business is all it takes to open the door to that first job. And once we get that first opportunity, we will almost always turn that person into a repeat customer either in the near future or somewhere down the road. Providing a quality product along with good, friendly service goes a long way.” -Pete Cummings As Pete reflects on the past seven years and especially 2020 when the pandemic first hit, he is thankful to be part of the Minuteman Press franchise family. He says, “We are very grateful for the efforts Minuteman Press International made fairly early on in the pandemic to help keep franchisees flourishing. There’s no question that things could have turned out differently. From continued guidance on how to operate as an essential business to initiating the free Bounce Back program to support local businesses, it was all instrumental in helping us navigate this unprecedented time.” When asked about the rewards of owning a business, Pete answers, “Financial freedom and the feeling that we can control our own destinies for us are the biggest rewards to business ownership. We can’t be the victim of a company downsize or see our jobs shipped overseas. We certainly work hard to achieve success but those efforts are going towards building something that directly benefits our families.” As for what advice he would give to local businesses right now, Pete sums it up best by saying, “Don’t lose heart. I know it has been a tough year but as more and more sectors of the economy ramp things up again, economic opportunities will return.” Pete Cummings and Chuck Bentley’s Minuteman Press franchise is located at 202 Wayne Dr., Ste. A; Richmond, KY 40475. For more information, call 859-314-1172 or visit their website: https://www.richmondky.minutemanpress.com. Learn more about #1 rated Minuteman Press franchise opportunities and read Minuteman Press franchise reviews at https://minutemanpressfranchise.com. Contact Details Minuteman Press International Chris Biscuiti +1 631-249-1370 cbiscuiti@mpihq.com Company Website https://minutemanpressfranchise.com

May 17, 2021 10:00 AM Eastern Daylight Time

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Calls for housing and landmarks for UK’s derelict land - Romal Capital survey

Romal Capital

With Britain still in the grip of an on-going housing crisis, property developers Romal Capital sought the views of the British public on regenerating derelict land and brownfield sites. The national survey* found that 59% of Brits are calling for derelict land to be converted into modern, efficient housing and a place for cultural landmarks. More the three-quarters (77%) feel that when brownfield sites are regenerated, they bring a sense of freshness, art and culture to an area improving the lives of everyone around it. However, as these sites stand, 74% believe that derelict sites are eyesores on the nations landscape. Romal Capital’s survey reported that over four-fifths (83%) of respondents feel Westminster governments have failed to prioritise regenerating brownfield sites in their area, in recent years. People in the North East of England (90%) felt strongest about this followed by those in the South East (85%). It follows that a lack of commitment from central government will have a regional impact. 79% of people pointed the length of time it takes for decisions to be made as the most significant hurdle to change. “It’s great to see that people across the country want see their areas improved and repurposed. However, it is clear that speed is the issue more than ambition says Romal Capital’s CEO Greg Malouf. Regeneration and planning have a lot of due process and extensive local bureaucracy, and it is this that needs to be restructured to get things going. Local authorities need more support and resources to streamline these processes and fast track regeneration of these sites.” What to do with all this space? A 2020 report** from the countryside charity CPRE found there was over 25,000 hectares of brownfield land across 21,000 sites in the UK. Enough to fit over 1 million homes. The survey discovered that almost a third (30%) of people would most like to see cultural landmarks built on this unused, derelict land, while a similar amount (29%) want to see modern, efficient homes and communities built to help solve the nations crippling housing crisis. When it comes to regenerated outdoor space, over a quarter, (26%) are in favour of new recreational facilities. “Many people are desperate for somewhere permanent to live and keen to see former industrial and undeveloped areas turned into new, progressive housing neighbourhoods and community hubs.” says Malouf “The authorities must become far more proactive and flexible to allow this to happen.” Notes to the editor *Research findings based on a survey of 2,000 UK households carried out in April 2021 for Romal Capital by LMRMC (Market Research Society approved partner and ESOMAR corporate member). **CPRE Report 2020 About Romal Capital Romal Capital is an international award-winning property developer based in Liverpool. The team brings to the city over 60 years of combined property development experience from across Liverpool, and other major UK and international cities. Contact Details Romal Capital Bilal Mahmood +44 7714 007257 b.mahmood@stockwoodstrategy.com Company Website https://www.romalcapital.co.uk/

May 12, 2021 06:30 AM Eastern Daylight Time

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Despite Gender Pay Gap, Women Lead The Next Wave of Wealth Transfer by Jennifer Lang Financial Services.

Jennifer Lang Financial Services, LLC

Contact Details Jennifer Lang Financial Services, LLC. Jennifer Lang +1 877-487-8926 mail@jenniferlangfinancialservices.com Company Website https://www.jenniferlangfinancialservices.com

May 11, 2021 10:05 AM Eastern Daylight Time

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EDUCATORS CAN FOSTER TRUST IN SCIENCE THROUGH GLOBAL PLEDGE

International Day of Light Steering Committee

For more than a year, educators worldwide have been forced to transform the way they teach. However, advancements in science, specifically telecommunications, enabled the shift from a traditional classroom to remote learning environments. Today, scientific developments, including health advancements such as vaccines and testing, are allowing students to return to physical classrooms. The Trust Science pledge, a worldwide campaign to promote support for the scientific process and acknowledge the many benefits of science for society, offers a valuable teaching tool to help educators draw attention to the crucial role science plays in improving our quality of life. In celebration of this year’s International Day of Light on 16 May, the pledge is allowing people, particularly educators and students, around the world to affirm their support for science and the scientific process. Students can be leaders in understanding and defending science. Just as educators teach skills that build students’ scientific literacy to help them evaluate facts, they can offer ways for students to affirm confidence in the scientific process. “A dedicated effort to building—and in some cases, rebuilding—trust in science will prepare students to be the scientifically informed leaders we desperately need,” said Dr. Desiré Whitmore, Senior Physics Educator and Staff Physicist at the Exploratorium in San Francisco, CA. Additional resources for educators are available on the Trust Science website, including hands-on activity videos, lesson plans, posters to download, activities and lessons, links to online resources and the Laser Classroom. To date, the pledge has seen enthusiastic support worldwide with more than 2,500 signatures, including Nobel and Breakthrough Prize laureates, UNESCO L’Oréal For Women in Science prize winners, Presidents and CEOs of major scientific bodies, as well as scientists and students from more than 20 different countries. The Trust Science campaign is organized by the IEEE Photonics Society, SPIE, the international society for optics and photonics, and The Optical Society (OSA), together with the International Day of Light Steering Committee. To sign the pledge and to learn more, please go to https://www.trust-science.org Contacts For questions about how you can engage with the campaign, please contact: info@trust-science.org For media inquiries, please contact: pr@trust-science.org Social media: please share using #TrustScience and #LightDay2021 Social media links: Facebook; Instagram; Twitter About the International Day of Light The International Day of Light (IDL) is a worldwide initiative that provides an annual focal point for the continued appreciation of light and the role it plays in science, culture and art, education and sustainable development, and in fields as diverse as medicine, communications and energy. The International Day of Light is administered from the International Basic Science Programme (IBSP) of UNESCO by a Steering Committee that includes representatives from a broad range of international partners: the American Institute of Physics (AIP), the American Physical Society (APS), Bosca, the China International Optoelectronic Exhibition (CIOE), Chinese Optical Society (COS), the European Centres for Outreach in Photonics (ECOP), the European Photonics Industry Consortium (EPIC), the European Physical Society (EPS), the Illuminating Engineering Society (IES), the International Centre for Theoretical Physics (ICTP), the IEEE Photonics Society (IPS), the International Commission on Illumination (CIE), lightsources.org - the international network of accelerator based light sources, Light: Science and Applications, The Optical Society (OSA), Tampere University, SPIE, the International Society for Optics and Photonics, SESAME, Signify, Tampere University, Thorlabs, Transitions, the Université de Franche-Comté and Velux. For information about the International Day of Light, please visit www.lightday.org Contacts for IDL: John Dudley and Joseph Niemela 2021 Steering Committee Chairs Email: contact@lightday.org Bethany Downer 2021 Communications Coordinator Email: contact@lightday.org Media Contact for Trust Science: pr@trust-science.org About IEEE Photonics Society The IEEE Photonics Society is the professional home for a global network of scientists, engineers and allied professionals who advance laser, optoelectronics, and photonics technology. As a technical society representing the IEEE, it is a vital part of the world’s largest technical professional organization of more than 400,000 members dedicated to advancing technology for the benefit of humanity. Through its highly cited publications, conferences, technology standards, educational activities, and humanitarian initiatives, the IEEE Photonics Society provides its members in more than 160 countries the opportunity to grow professionally and stay on the forefront of transformational breakthroughs in photonics. PhotonicsSociety.org About SPIE SPIE, the international society for optics and photonics, was founded in 1955 to advance light-based technologies. Serving more than 255,000 constituents from 183 countries, the not-for-profit society advances emerging technologies through interdisciplinary information exchange, continuing education, publications, patent precedent, and career and professional growth. SPIE annually organizes and sponsors approximately 25 major technical forums, exhibitions, and education programs in North America, Europe, Asia, and the South Pacific. In 2020, SPIE provided more than $5 million in support of education and outreach programs. www.spie.org About The Optical Society Founded in 1916, The Optical Society (OSA) is the leading professional organization for scientists, engineers, students and business leaders in light science and technology. The society serves over 432,000 customers and 22,000 members from more than 100 countries who fuel discoveries, shape real-life applications and accelerate achievements in the field. OSA provides quality research, inspired interactions and dedicated resources for its extensive global network of optics and photonics experts through world-renowned publications. For more information, visit osa.org. Contact Details pr@trust-science.org +1 703-907-0010 pr@trust-science.org Company Website https://www.trust-science.org

May 11, 2021 09:03 AM Eastern Daylight Time

Hong Kong Baptist University and Cornell University jointly develop a novel nano-carrier that increases the efficacy of Chinese medicine treatment for breast cancer

Hong Kong Baptist University

HONG KONG SAR - Media OutReach - 11 May 2021 - Researchers from Hong Kong Baptist University (HKBU), in collaboration with Cornell University, have developed a novel targeted therapy for triple-negative breast cancer (TNBC) that uses a specially-designed nano-carrier to deliver the Chinese medicine compound gambogic acid (GA). The invention enhances the anti-cancer effect of GA and reduces its damage to off-target organs. The invention has the potential to become a more effective therapeutic option for TNBC. The study was supported by the Vincent and Lily Woo Foundation, and the research findings have been published in the international medical journal Frontiers in Oncology. GA as a breast cancer treatment and its limitations TNBC accounts for 10-24% of all breast cancer cases and it also grows and spreads faster than other types of breast cancer. There are limited treatment options for TNBC and it has a high risk of recurrence and metastasis. In the advanced stage of the disease, the five-year relative survival rate is only about 12%. GA is a herbal compound isolated from a dry, brownish resin called gamboge, which is derived from Garcinia hanburyi, a plant with a long history of medicinal use in Southeast Asia. Previous studies have shown that GA can inhibit the growth of cancer cells. However, its clinical application is limited by the fact that it is rapidly eliminated from the circulation system and has poor water solubility, which makes it difficult for GA to reach the cancer cells. Furthermore, high dosages of GA can cause damage to off-target organs due to its toxicity. Nano-carrier increases treatment efficacy of GA In the search for a more effective treatment protocol for TNBC when compared to existing options, Professor Bian Zhaoxiang, Director and Tsang Shiu Tim Endowed Professor in Chinese Medicine Clinical Studies of the Clinical Division of HKBU’s School of Chinese Medicine (SCM) and Dr Kwan Hiu-yee, Assistant Professor of the Teaching and Research Division of SCM, together with the research team of Professor Chu Chih-Chang at Cornell University, designed a novel nano-carrier to enhance GA’s efficacy as a TNBC treatment and reduce its off-target toxicity. The researchers made a bio-degradable nano-carrier out of polyester urea urethane (PEUU), and they decorated it with folate (also known as vitamin B9) and arginine (an amino acid). Folate receptors are highly expressed in TNBC cells, and they can serve as a target for therapy. Arginine is a positively charged amino acid, and it can attract the nano-carrier to the negatively charged tumour surface. These features enable the nano-carrier to target and deliver GA effectively to TNBC cells. Treatment efficacy tested in mice The research team tested the efficacy of the GA-loaded nano-carrier as a TNBC treatment in a series of mouse experiments. Two groups of mice with TNBC were treated with the same dosage of GA, one in the form of the GA-loaded nano-carrier, and the other in the form of free GA. After 17 days of treatment, the average reduction in tumour weight of the GA-loaded nano-carrier group was 67.6% higher than the free GA group. The results showed that the GA-loaded nano-carrier is more effective at shrinking the tumours than the free GA. In addition, the group treated with the GA-loaded nano-carrier had 0.23 μg/mL of GA in their tumours two hours after injection, and the tumour GA concentration of the GA-loaded nano-carrier group was three times of the free GA group, showing that GA is being delivered to TNBC cells more effectively with the nano-carrier. Also, the concentration of GA in the plasma of the GA-loaded nano-carrier group two hour after injection was nearly three times of the free GA group, showing that the GA carried by the nano-carrier stays in the circulation system for longer. Reduced off-target damage to other organs Furthermore, when compared with free GA, the GA delivered by the nano-carrier caused less damage to the off-target organs of the mice including their hearts, livers and lungs. It also caused minimal damage to their kidneys and spleens as relatively low levels of GA were detected in these two organs. “As demonstrated in our study, the novel nano-carrier for GA offers many benefits when it comes to treating TNBC,” said Dr Kwan Hiu-yee. “The application of nanotechnology in this study modernises the delivery of Chinese medicine, thereby enhancing its therapeutic efficacy. We believe that our nano-carriers have great clinical potential to treat TNBC and other types of cancer,” said Professor Bian Zhaoxiang. Contact Details Hong Kong Baptist University Kevin Lau from the Communication and Public Relations Office kevinkflau@hkbu.edu.hk Company Website https://www.hkbu.edu.hk/

May 11, 2021 09:00 AM Eastern Daylight Time

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