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NRx Pharmaceuticals founder unveils potential treatment for suicidal thoughts and depression

NRx Pharmaceuticals Inc

NRx Pharmaceuticals founder and chief scientist Dr Jonathan Javitt joined Steve Darling from Proactive to discuss groundbreaking developments in treating suicidal ideation and depression. NRx focuses on targeting the NMDA (N-methyl-D-aspartate) receptor in the brain, identified as crucial for turning off suicidal thoughts. Traditional antidepressants, which target the serotonin axis, often increase suicide risk, highlighting the need for a new approach. Javitt told Proactive the company is approaching the clinical trial enrollment goals for its partnered product NRX-101, while opening new clinical initiatives in chronic pain, urinary tract infection, and NRX-100 for suicidal depression. The company said the trial is near completion of enrollment of the originally-targeted 70 participants in the Phase 2b/3 trial of NRX-101. Top-line data from this cohort of patients is expected shortly after the last patient visit. Javitt told Proactive chronic pain affects more than 50 million American adults, compared to the approximately 3 million who report thoughts of suicide on an annual basis. There has been no new non-opioid class of drugs to treat nociceptive pain in the past two decades and NRX-101 has the potential to be the first NMDA-antagonist drug to seek approval for this indication. Contact Details Proactive Investors +1 604-688-8158 na-editorial@proactiveinvestors.com

November 16, 2023 02:07 PM Eastern Standard Time

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Navigating Open Enrollment

YourUpdateTV

Open Enrollment season is underway, and as we look ahead to 2024, now is the time to assess health care coverage options and select the plan that is best for you and your budget. Recently, Rhonda Randall, the Chief Medical Officer of UnitedHealthcare Employer and Individual participated in a nationwide satellite media tour to share tips for navigating the Open Enrollment season. A video accompanying this announcement is available at: https://youtu.be/mhpkMs2vBGk Enrollment periods aren’t the same for everyone, so there are key dates to keep in mind depending on your circumstances. Many employers set aside a 2- to 3-week period between September and December when employees can select health benefits for the following year. But just as millions of Americans prepare to choose health insurance for next year, a recent survey revealed that 1 in 3 people (36%) spend less than 1 hour reviewing their benefits options. For most people, not making an enrollment decision means you may be locked into your current plan for the upcoming year. If anything has changed this year – either with your current plan, health status or budget – that decision to do nothing could lead to unpleasant surprises or missed cost-savings in 2024. Because everyone has unique health and budget needs, and there is no one-size-fits-all approach to selecting a health plan, it’s important to stay informed before making these decisions. When choosing a health plan, here are a handful of tips that will hopefully lead to better health and cost savings: Take your time and consider all of your options Learn the language Help prevent financial surprises Check for mental health coverage Don’t forget about specialty benefits Look into wellness programs Explore virtual care services Visit UHCOpenEnrollment.com for tips, resources and information on plans in your area About Rhonda Randall Rhonda L. Randall, D.O., is the Chief Medical Officer of UnitedHealthcare Employer & Individual, the nation’s largest business serving the health coverage and well-being needs of nearly 28 million Americans. Dr. Randall collaborates with U.S. employers who are looking for quality, cost-effective, long-term solutions to health benefits for their employees and retirees. She also leads the clinical strategy development for these businesses to improve quality outcomes, ensure affordability and improve health and well-being. Contact Details YourUpdateTV +1 212-736-2727 yourupdatetv@gmail.com

November 16, 2023 11:00 AM Eastern Standard Time

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Thrive Precision Health, Inc. (OTC:CNER) Taking Steps To Serve Diabetic Health Sector

China New Energy Group Co

In the world of healthcare investments, the diabetes care market emerges as a compelling arena ripe with opportunities. Several important factors that may attract some investors are driving the sector's growth. At the heart of this surge is the continual development of efficient insulin delivery devices. Technological advancements in healthcare are steering manufacturers to innovate in this crucial area. Projections indicate a substantial uptick in the global diabetes care devices market, from $28,942.1 million in 2022 to an anticipated $42,119.3 million by 2028, reflecting a noteworthy compound annual growth rate (CAGR) of 6.4%. The World Health Organization's recognition of diabetes as a significant global health challenge underscores the urgency for solutions. With over 420 million people affected worldwide, the market demands innovative approaches to address this widespread concern. The insulin market, valued at $21.11 billion in 2022, signifies a substantial financial domain within the broader diabetes care landscape. Predictions hint at its growth to $25 billion by 2030, with North America playing a prominent role, commanding a considerable 38.91% market revenue share in 2022. On a domestic scale, the United States presents a vivid picture of the diabetes epidemic. A staggering 37.3 million Americans are diagnosed with diabetes, while an additional 96 million grapple with pre-diabetes. This prevalence is particularly pronounced in the aging population, where 48.8% of those aged 65 or older face the challenges of this health condition. Looking forward, Global Market Insights anticipates a robust compound annual growth rate of 10% for the diabetes care device market. This projection positions the market to evolve into an $88 billion industry by 2030, offering investors a compelling narrative for potential opportunities in this evolving healthcare landscape. Among the growing landscape of the diabetes care market, one potential hidden gem poised for prominence is Thrive Precision Health, Inc. (OTC: CNER). Thrive Precision Health Inc. is carving its niche as a global diabetes care powerhouse. Trading under the symbol CNER, the company is revitalizing established healthcare clinics specializing in diabetes care. Their unique approach integrates cutting-edge technologies, aiming to create a seamless digital experience for patients worldwide, offering personalized healthcare through the application of AI and quantum biosensors. The company marked a significant milestone on October 5, 2023, by completing a name change to Thrive Precision Health, Inc. This strategic move accompanied the establishment of two wholly-owned subsidiaries, Thrive Testing and Biosafety Inc. and Thrive Precision Health (USA), Inc., signaling a commitment to precision health and a broader global vision. Thrive Precision Health's expansion strategy takes center stage with a recent press release announcing a binding letter of intent to acquire two diabetes clinics in Arizona. The pending acquisition of True Diabetes Neuropathy and Wounds Solutions AZ, LLC, marks the initiation of their strategy to infuse advanced technology into diabetes care. The company is diligently developing a standardized clinical footprint designed for scalability across the nation and internationally. Each clinic is expected to offer a range of services, including wound care, IV therapies, neuropathy treatment, and complementary protocols. With up to 20 IV stations and five wound care treatment rooms per clinic, Thrive envisions generating $5–6 million in total revenues per location, aiming for an impressive 35% EBITDA within each clinic. Guy Zajonc, CEO and Chairman of Thrive Precision Health, is a prime example of the company's leadership, which places a strong emphasis on precision health and personalized medicine. The CEO of True Diabetes, Dr. Jason Mulder, draws attention to the urgent need in Arizona alone, where millions of people suffer from diabetes and there is a severe shortage of treatment resources. In the context of a burgeoning diabetes care market, Thrive Precision Health, Inc. (OTC: CNER) emerges as a compelling player with a vision to transform healthcare delivery. Their strategic acquisitions, commitment to precision health, and innovative approach position them as an intriguing opportunity within a sector poised for significant growth. As the demand for personalized diabetes care rises, CNER stands out as a potential cornerstone in this evolving narrative. Disclaimers: The Private Securities Litigation Reform Act of 1995 provides investors a safe harbor in regard to forward-looking statements. Any statements that express or involve discussions with respect to predictions, expectations, beliefs, plans, projections, assumptions, objectives, goals, or assumptions of future events or performance are not statements of historical fact may be forward looking statements. Forward looking statements are based on expectations, estimates, and projections at the time the statements are made that involve a number of risks and uncertainties which could cause actual results or events to differ materially from those presently anticipated. Forward looking statements in this action may be identified through use of words such as projects, foresee, expects, will, anticipates, estimates, believes, understands, or that by statements, indicating certain actions & quotes; may, could or might occur Understand there is no guarantee past performance is indicative of future results. Investing in micro-cap or growth securities is highly speculative and carries an extremely high degree of risk. It is possible that an investor's investment may be lost or due to the speculative nature of the companies profiled. Capital Gains Report (CGR) is responsible for the production and distribution of this content. CGR is not operated by a licensed broker, a dealer, or a registered investment advisor. It should be expressly understood that under no circumstances does any information published herein represent a recommendation to buy or sell a security. CGR has been retained by ACN LLC to produce and distribute this content related to CGER. As part of that content, readers, subscribers, and webs are expected to read the full disclaimers and financial disclosure statement that can be found on our website capitalgainsreport.com All content in this article is information of a general nature and does not address the circumstances of any particular individual or entity. Nothing in this article constitutes professional and/or financial advice, nor does any information in the article constitute a comprehensive or complete statement of the matters discussed or the law relating thereto. CGR is not a fiduciary by virtue of any persons use of or access to this content. Contact Details Capital Gains Report Mark McKelvie +1 585-301-7700 markrmckelvie@gmail.com Company Website http://CapitalGainsReport.com

November 16, 2023 10:00 AM Eastern Standard Time

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PathAI Announces AISight Support of DICOM Standards and Commits to Being a Leader in Integrated Enterprise Image Architecture and Strategy

PathAI

PathAI, a leading technology company which combines AI-powered pathology solutions with end-to-end central pathology and histology services, today announced that AISight™ [1] supports rendering DICOM® Visible Light (VL) Whole Slide Microscopy Image files. AISight is a state-of-the-art, interoperable, intelligent case and image management system to assist pathologists in the review of digitized whole slide images (WSIs) with a comprehensive menu of fully embedded AI solutions. The incorporation of modern digital pathology into the DICOM standard was finalized in 2010, allowing organizations to integrate digital pathology into their existing IT systems, providing vendor flexibility, and enabling integrated storage with other imaging modalities (e.g., radiology) in vendor neutral archives (VNAs). DICOM support is a major advancement towards enabling PathAI’s vision of interoperable pathology systems that fit seamlessly into providers current or future enterprise image architecture and strategy. “We’ve been collaborating with many large academic medical centers and health systems over the last year to provide consultative support on digitalization of pathology workflows. In these discussions, one thing is clear. Chief information officers (CIOs) and enterprise imaging architects are pushing for vendors to adopt DICOM to drive imaging interoperability,” said Don O’Neill, SVP of Engineering and IT at PathAI. “PathAI is committed to doing just that and being able to render DICOM image files is the first step in that direction.” As part of its investment into DICOM, PathAI is making a commitment to interoperability and providing solutions that integrate with organizations’ enterprise image management and archive strategy, including through VNAs. PathAI will also launch its DICOMweb API in its next release, which will enable AISight to receive DICOM images from external applications, push images back to VNAs leveraging customer’s DICOMweb API, utilize the DICOM file to supplement or validate image/case data, and enable prefetch to pull historical cases/studies directly from image archives. “By investing into interoperability with enterprise image archives, we’re demonstrating to our customers that we are strategically positioned to provide long term value. No matter where a customer is in the imaging journey, we can help them,” said Andy Beck, MD, PhD, co-founder and chief executive officer of PathAI. To learn more about this integration, visit www.PathAI.com or meet with our team at upcoming conferences including Digital Pathology & AI Congress Europe, London (Booth #30, December 7-8). 1- AISight is for Research Use Only. Not for use in diagnostic procedures. About PathAI PathAI is the only AI-focused technology company to provide comprehensive precision pathology solutions from wet lab services to algorithm deployment for clinical trials and diagnostic use. Rigorously trained and validated with data from more than 15 million annotations, its AI-powered models can be leveraged to optimize the analysis of tissue samples to improve efficiency and accuracy of pathology interpretation, as well as to better gauge therapeutic efficacy and accelerate drug development for complex diseases. PathAI, which is headquartered in Boston, MA, and operates a CAP/CLIA-certified laboratory in Memphis, TN, is proud to be a rapidly expanding organization of innovative thinkers from around the globe. For more information, please visit www.pathai.com. Contact Details SVM Public Relations and Marketing Communications Maggie Naples +1 401-490-9700 pathai@svmpr.com Company Website https://www.pathai.com/

November 16, 2023 10:00 AM Eastern Standard Time

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Gattaca CEO focused on "rebuilding the business in a really sustainable way"

Gattaca PLC

Gattaca PLC CEO Matthew Wragg speaks to Thomas Warner from Proactive about how the STEM-focused talent solutions company has been performing during a challenging period in the market. Wragg discusses the final results for the year ending in July, highlighting a profit before tax of £2.6 million which marginally exceeded expectations. This positive trajectory comes within the context of a sluggish market, especially in permanent placements, which experienced a slowdown. He expresses optimism about Gattaca's direction, emphasising the internal changes and improvements made over the last 18 months. He noted that the company's focus on STEM skills helps add to its resilience. The conversation also touched on Gattaca's recent decision to relaunch its share buyback. Wragg outlined the rationale behind the move, citing a healthy cash position. Looking ahead, Wragg emphasises the importance of rebuilding corporate memory and fostering a positive environment for success and says he's focused on "rebuilding the business in a really sustainable way." Contact Details Proactive Investors +44 20 7989 0813 uk@proactiveinvestors.com

November 16, 2023 06:20 AM Eastern Standard Time

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Cure Alzheimer’s Fund Launches WomenandAlzheimers.org

Alzheimer’s Disease Research Foundation

In honor of National Alzheimer’s Disease Awareness Month, Cure Alzheimer’s Fund announces the launch of WomenandAlzheimers.org, a website dedicated to bringing awareness to the impact of Alzheimer’s on women, providing information on research into understanding sex-based differences and recognizing many of the women who are working toward finding a cure. There are more than 6 million people in the United States—and 50 million people throughout the world—currently living with an Alzheimer’s diagnosis, and experts estimate there may be as many as three times more people living with the disease who have not yet been diagnosed. Both men and women develop Alzheimer’s disease, but two-thirds of all patients are women, and women are frequently the primary caregivers for spouses, partners, parents and others with the disease. “For far too long, science has had a partial view into disease biology because only one sex was included in research studies,” said Meg Smith, CEO of Cure Alzheimer’s Fund. “Cure Alzheimer’s Fund has long required researchers to include consideration of potential sex differences in their projects. Understanding why and how Alzheimer’s develops differently in men and women, and the factors that increase resilience or risk, will lead to benefits for all Alzheimer’s patients.” WomenandAlzheimers.org is a resource to learn more about Alzheimer’s disease pathology, signs and symptoms, and the scientific discoveries that are advancing our understanding of the disease. Users can learn about ways to improve brain health, at any age, and read about the women who are working to find a cure, including researchers, Board members, staff members and advocates. About Cure Alzheimer’s FundCure Alzheimer’s Fund is a nonprofit dedicated to funding the most promising research to prevent, slow or reverse Alzheimer’s disease. Since its founding in 2004, Cure Alzheimer’s Fund has provided grants to the world’s leading researchers and contributed more than $180 million to research. Its funded initiatives have been responsible for many key breakthroughs in understanding the causes and pathology of Alzheimer’s disease. Cure Alzheimer’s Fund has received a 4-star rating for more than 12 consecutive years from Charity Navigator. With 100% of funds raised going to support research, Cure Alzheimer’s Fund has been able to provide grants to many of the best scientific minds in the field of Alzheimer’s research. For more information, visit https://WomenandAlzheimers.org and https://www.CureAlz.org/ Contact Details Barbara Chambers +1 978-417-9890 bchambers@curealz.org Company Website https://WomenandAlzheimers.org

November 15, 2023 05:46 AM Eastern Standard Time

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Nevis Brands announces company is expanding into Michigan with signature brand Major

Nevis Brands

Nevis Brands CEO John Kueber joined Steve Darling from Proactive to share significant news regarding the company's expansion into Michigan, marking its eighth state in the cannabis market. Nevis Brands has secured an exclusive agreement with Emerald Canning Partners to produce and distribute Major products in the state of Michigan, subject to approval by the Michigan Cannabis Regulatory Agency. Michigan is a strategically important market for Nevis Brands, as it witnessed cannabis sales totaling $2.3 billion in 2022, and it is expected to exceed the $3 billion mark in 2023. This makes Michigan the second territory in the Eastern United States where Nevis is establishing a licensee. Under the agreement with Emerald Canning Partners, Nevis Brands will have exclusive rights to produce and distribute all five flavors of Major, including Sunset Pink Lemonade, Pacific Blue Raspberry, Sacred Grape, Volcanic Orange Mango, and Passionfruit. Major is a dosable 100mg THC beverage known for delivering the effects of cannabis within 10-20 minutes of consumption. This expansion into Michigan represents a significant step for Nevis Brands as it continues to grow its presence in the rapidly evolving cannabis market. With its innovative Major product line and strategic partnerships, Nevis is well-positioned to capitalize on the increasing demand for cannabis products and provide consumers with unique and high-quality options. Contact Details Proactive Canada +1 604-688-8158 na-editorial@proactiveinvestors.com

November 14, 2023 01:49 PM Eastern Standard Time

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Immunic focusing on business development during Q4

Immunic Inc

Immunic Inc President and CEO Dr Daniel Vitt speaks to Thomas Warner from Proactive London after the Munich-based biotech company released a third-quarter update. Dr Vitt starts by describing the quarter as a "very eventful and positive quarter for us, dominated by a key message" - positive interim data from its Phase 2 CALLIPER trial of vidofludimus calcium in Progressive Multiple Sclerosis. The financial aspect was also discussed, with the company claiming a cash reserve of $60 million as of the last quarter. The interview highlights the company's efforts to bolster its intellectual property portfolio, citing a notice of allowance from the US Patent Office for the vidofludimous calcium dose strength patent. Dr Vitt discusses the company's focus on business development during the current quarter, expressing confidence in the data and molecules its bringing to discussions with potential partners. He says that "the focus for the company is clearly on the business development side... we [also] continue execution of the vidofludimous MS programs and also prepare a potential phase 2 clinical study for IMU-856." Contact Details Proactive United States +1 347-449-0879 na-editorial@proactiveinvestors.com

November 14, 2023 01:25 PM Eastern Standard Time

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MGC Pharmaceuticals reveals strategic objectives for H1 2024

MGC Pharmaceuticals Ltd

MGC Pharmaceuticals Ltd CEO and Managing Director Roby Zomer speaks to Thomas Warner from Proactive London following the completion of a share consolidation and capital raise. With these restructuring initiatives completed, Zomer shares his enthusiasm for the future of the plant-based pharmaceutical company and outlines the strategic roadmap for 2024. Zomer emphasises the importance of the recent share consolidation, which involved restructuring the company's capital and introducing new investors aligned with MGC Pharma's long-term vision as a pharmaceutical entity. The CEO highlighted that this move would facilitate the execution of the company's 2024 work plan, presented over the past six months during various roadshows. Acknowledging the impact of the restructuring on existing shareholders, Zomer expresses optimism about the real opportunity it now presents. He explained that the capital raised in the past 18 months, coupled with new long-term investors, positions MGC Pharma to build a sustainable future, providing returns to shareholders who faced dilution. Looking ahead to 2024, Zomer outlined key initiatives in the company's work plan. The focus will be on completing studies on CimetrA, a drug with potential applications, to enable submission to the FDA for an Investigational New Drug (IND) designation. Simultaneously, ongoing clinical trials will pave the way for seeking early access schemes in the United States and eventually obtaining marketing authorization globally. The second drug, CannEpil, designed for drug-resistant epilepsy, will also undergo enrolment and IND submission, with efforts split evenly between both drugs. Zomer highlights the commercial focus on CannEpil in the UK and Ireland, but says CimetrA takes precedence in terms of IND submission, with both drugs considered essential for the company's progress. As the pharmaceutical landscape evolves, Zomer anticipates increased sales of CimetrA through existing schemes, additional purchase orders, and revenue growth. By mid-2024, Zomer envisions CimetrA entering the IND process, with results from dose-finding studies and the initiation of the IND submission for CanAppeal. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

November 14, 2023 12:57 PM Eastern Standard Time

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