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With Rise In Pancreatic Cancer, Oncotelic Therapeutics (OTCQB: OTLC) Opens Up Enrollment For STOP-PC Clinical Trial

Benzinga

By Faith Ashmore, Benzinga Unfortunately, an increase in early-onset pancreatic cancer has garnered significant media attention lately. From 2010-2019, gastrointestinal cancer rates jumped almost 15% for people under 50, alarming doctors around the globe. With only a 12% five-year survival rate, pancreatic cancer is anticipated to become the second leading cause of cancer-related deaths in the U.S. by 2030. It is projected that 64,440 Americans will receive a pancreatic cancer diagnosis in 2024. In 2022, the global market for pancreatic cancer was valued at $2.22 billion, and it is projected to reach approximately $7.91 billion by 2032. This highlights a crucial need for more therapeutic options for pancreatic cancer. Oncotelic Therapeutics (OTCQB: OTLC), a therapeutics company with a focus on cancer and viral infection treatments, is attempting to provide more hope for Americans who are facing a pancreatic cancer diagnosis. The company’s lead immuno-oncology drug candidate is OT-101. Oncotelic Therapeutics says it is showing promise in the treatment of deadly cancers like pancreatic cancer. It is a first-in-class anti-TGF-β RNA therapeutic that inhibits a protein called Transforming Growth Factor Beta (TGF-β). TGF-β is known to suppress the immune system, help cancer cells evade the immune system and increase the growth and spread of cancer cells. Clinical Trial For OT-101 Phase 2 studies of OT-101 have shown promising results in treating pancreatic cancer, melanoma and glioblastoma, with strong efficacy and safety outcomes among treated patients. Pancreatic cancer is one of the most highly aggressive types of cancer that can be difficult to treat and has a high unmet need. Oncotelic Therapeutics is now seeking participants for its upcoming STOP-PC clinical trial. The trial aims to evaluate the effectiveness of the TGF-β2 Targeting Antisense Oligonucleotide OT-101 in combination with mFOLFIRINOX compared to mFOLFIRINOX alone in patients with advanced and unresectable or metastatic pancreatic cancer. Previous data has shown that OT-101 has significant activity as a standalone treatment, with reported overall survival rates surpassing existing drug outcomes. In this phase 2/3 trial, participants will be assigned to either receive OT-101 plus mFOLFIRINOX or mFOLFIRINOX alone as second-line therapy after their cancer has progressed. "STOP-PC trial is the combination of mFOLFIRINOX and OT-101 based on our demonstration that reduced TGF- β2 resulted in outstanding improvement in survival among patients treated with Irinotecan with survival beyond 34 months for the low TGF-β2 expression cohort. The mFOLFIRINOX was chosen as the most well tolerated combination of choice through discussion with regulatory authorities and key opinion leaders. We believe this trial will deliver the decisive win against pancreatic cancer," said Dr. Vuong Trieu, CEO of Oncotelic. To learn more about participation in STOP-PC Clinical Trial click here or watch this explainer video here. Featured photo by Alexander Grey on Unsplash. Benzinga is a leading financial media and data provider, known for delivering accurate, timely, and actionable financial information to empower investors and traders. This post contains sponsored content. This content is for informational purposes only and is not intended to be investing advice. Contact Details Benzinga +1 877-440-9464 info@benzinga.com Company Website http://www.benzinga.com

April 10, 2024 08:30 AM Eastern Daylight Time

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Vivos Therapeutics receives approval for Medicare reimbursement for flagship Oral Medical Devices

Vivos Therapeutics

Vivos Therapeutics CEO Kirk Huntsman joined Steve Darling from Proactive shared significant news regarding the regulatory approval for Medicare reimbursement of their oral medical devices designed for sleep apnea treatment. Huntsman emphasized the unique design of Vivos's medical devices, which are capable of enhancing the human airway and potentially eliminating sleep apnea symptoms after a 12-month treatment period. This FDA clearance positions Vivos as the only line of oral medical devices globally that can treat severe sleep apnea. The approval for Medicare reimbursement is described as a monumental achievement, as it is expected to benefit tens of millions of Medicare patients suffering from moderate to severe obstructive sleep apnea (OSA) without the need for lifetime intervention. This recognition by the Centers for Medicare and Medicaid Services (CMS) propels Vivos's devices as a viable alternative to traditional CPAP treatments, especially timely given the recent recalls in the CPAP market and Philips' withdrawal from the U.S. market. Huntsman expressed his excitement about the broader implications of this approval, including increased recommendations of Vivos's treatments by medical and dental providers and a growing awareness of their efficacy as an alternative to CPAP treatments. This development represents a significant step forward in transforming patient care for individuals suffering from sleep apnea. Watch the full interview to learn more about Vivos Therapeutics Inc.'s pioneering approach to treating sleep apnea and their vision for improving patient care. Contact Details Proactive Investors +1 347-449-0879 na-editorial@proactiveinvestors.com

April 09, 2024 11:45 AM Pacific Daylight Time

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hVIVO achieves record revenue and initiates dividend policy following successful year

hVIVO PLC

hVIVO PLC (AIM:HVO) chief executive Yamin 'Mo' Khan discusses the company's record-breaking financial results in 2023 in an interview with Proactive's Stephen Gunnion. hVIVO announced a 16% year-on-year growth in revenue, reaching £56 million, with an EBITDA margin increase from 18.7% to 23.3%, surpassing prior guidance. The company's absolute EBITDA rose to £30 million, a 44% increase from the previous year. Khan attributed the success to hVIVO conducting more human challenge trials, leading to improved patient recruitment efficiency and better utilisation of facilities and staff. Despite challenges such as MHRA delays, significant funding for a new Canary Wharf facility positively impacted the financial results. hVIVO also initiated an annual dividend policy, planning a £1.4 million dividend distribution following a strong cash generation year. The Canary Wharf facility's development, notably ahead of schedule, includes a 50-bed quarantine facility and a laboratory, set to be fully operational by the end of July. This expansion is expected to enhance operational efficiency, increase revenue potential to up to £95 million, and strengthen hVIVO's position in the human challenge trial industry globally. For 2024, the company anticipates hitting a £62 million revenue target, with £180 million in the weighted order book ensuring a robust pipeline. Despite a study cancellation, hVIVO remains confident in its revenue and EBIT margin targets. Looking forward, hVIVO aims for a £100 million revenue target by 2028, driven by expanding its human challenge trials, increasing clinical trial services, and exploring M&A activities, supported by a strong cash reserve. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

April 09, 2024 07:51 AM Eastern Daylight Time

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Genflow Biosciences attracts new institutional investors with £715,000 fundraise

Genflow Biosciences PLC

Genflow Biosciences PLC (LSE:GENF, OTCQB:GENFF) CEO Dr Eric Leire tells Proactive's Stephen Gunnion the company has successfully raised £715,000 through a mix of placements and subscriptions for new stock. This fundraising effort was notably supported by company directors, including Leire, and new institutional investors. Leire highlighted the importance of this move as a strategic effort to stabilise and grow the company, especially noting the significance of attracting institutional investment. Historically, Genflow relied on grants and research funding, making this step a notable shift in its funding strategy. Leire also mentioned the company's focus on longevity and healthspan, pointing out the increasing gap between lifespan and healthspan as a major healthcare and economic challenge. Genflow's approach to addressing age-related diseases has started to attract attention from the institutional market, recognizing the potential high upside in the longevity sector. The funds raised are earmarked for continuing clinical trials in their three main programs: progeria, non-alcoholic steatohepatitis (NASH), and sarcopenia, aiming to reduce both financial and scientific risks by diversifying their portfolio. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

April 08, 2024 11:13 AM Eastern Daylight Time

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FendX Technologies Innovates Surface Protection with Nanotechnology

FendX Technologies Inc

FendX Technologies CEO Carolyn Myers joined Steve Darling from Proactive to share updates about FendX Technologies, a company pioneering the development of nanotechnology-based products designed to protect high-touch surfaces from contamination. Myers explained that FendX's innovations, licensed from McMaster University nearly four years ago, are focused on creating surfaces to which bacteria, viruses, and organic substances do not adhere, boasting efficacy rates of 95% or higher. These products include a film with an adhesive backing for easy application and a spray offering broader application, both providing 24-hour protection against contaminants. The company is targeting the healthcare sector, particularly hospitals and long-term care facilities, as well as high-traffic areas such as transportation hubs, schools, and malls. The goal is to mitigate the transmission of potentially lethal pathogens in these environments. Following a recent private placement, FendX is gearing up for the commercialization of its REPELWRAP Film and advancing the spray to be commercialized in 2025. Ongoing developments in the product lineup are also underway to further combat surface contamination. Overall, FendX Technologies is focused on leveraging nanotechnology to create innovative solutions for surface protection, aiming to contribute to public health and safety in various sectors. Contact Details Proactive North America Proactive North America +1 604-688-8158 NA-editorial@proactiveinvestors.com

April 08, 2024 07:38 AM Eastern Daylight Time

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Non-addictive options to Opioids: Exploring Pain Relief Options Before Taking Opioids

YourUpdateTV

A video accompanying this announcement is available at: https://youtu.be/RjjYJwM-XFc While opioid dispensing rates in the U.S. are slowly ticking down, they remain elevated compared with rates in other countries. The U.S. makes up only 4.4% of the world’s population, but it consumes over 80% of the world’s opioids Luckily, consumers today have more options than ever before for powerful, nonaddictive pain relief as they navigate their unique positions on the overall pain spectrum, including but not limited to over-the-counter (OTC) medications, physical therapy, medication and chiropractic care. Mothers Against Prescription Drug Abuse (MAPDA) in partnership with Aleve®, a marquee pain relief product from Bayer indicated for minor pain, launched “The Painful Truth,” campaign developed to encourage consumers to explore, with their doctors, pain relief options such as OTC products before taking opioids, when appropriate. “The Painful Truth” campaign launched with a film featuring real pain sufferers who are at crossroads in their pain relief journeys and seeking guidance. The featured patients believe they are participating in a video call with a pain expert who will help them explore their options, but as the conversation progresses, our “expert” reveals that they are in fact in recovery from opioid use disorder. At this critical juncture in their care, the patients are encouraged to consider different pain relief options. A nationwide media tour was conducted on March 26th featuring Mary Bono, Co-Founder, Chair of the Board of Directors & CEO of Mother’s Against Drug Abuse (MAPDA) and Matt Robinson, A voice from “The Painful Truth” campaign and Co-Host of Till the Wheels Fall Off (TWFO) podcast. Topics that were discussed included: · What people need to know about the pain relief options available to them before taking opioids when appropriate and after discussion with their healthcare provider. · Matt’s first-person experience with opioid use disorder. · The work Mother’s Against Drug Abuse has done to address the issue. · How patients can choose and advocate for themselves as it relates to pain management. For more information, visit aleve.com/thepainfultruth. About with Mothers Against Prescription Drug Abuse (MAPDA) Founded in 2011, Mothers Against Prescription Drug Abuse is a nationally recognized 501(c)(3) nonprofit organization focused on policy advocacy, opioid use disorder (OUD) prevention education, and opioid awareness programs. For more information, visit mapda.net. About Bayer Bayer is a global enterprise with core competencies in the life science fields of health care and nutrition. In line with its mission, “Health for all, Hunger for none,” the company’s products and services are designed to help people and the planet thrive by supporting efforts to master the major challenges presented by a growing and aging global population. Bayer is committed to driving sustainable development and generating a positive impact with its businesses. At the same time, the Group aims to increase its earning power and create value through innovation and growth. The Bayer brand stands for trust, reliability and quality throughout the world. In fiscal 2023, the Group employed around 100,000 people and had sales of 47.6 billion euros. R&D expenses before special items amounted to 5.8 billion euros. For more information, go to www.bayer.com. Contact Details YourUpdateTV +1 212-736-2727 yourupdatetv@gmail.com

April 05, 2024 10:39 AM Eastern Daylight Time

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Unlocking the Power of Immunotherapy: Elicio Therapeutics’ (NASDAQ: ELTX) Novel AMP Platform

Benzinga

By Jeremy Golden, Benzinga Approximately two million people were diagnosed with cancer in the U.S. in 2023, with breast, prostate, lung and bronchus cancers among the most common. An estimated 609,820 people died of cancer last year. The most common treatments are surgery, chemotherapy and radiation, though other options include targeted therapy as well as laser and hormonal therapies. Another treatment option is immunotherapy, which is designed to utilize the immune system to fight cancer. Immune responses are orchestrated by key immune cells in the lymph nodes, but for many therapies, getting to these critical sites is far from certain. Small molecule-based immunomodulators easily pass through the blood vessel walls at the injection site. As a result, they are rapidly flushed away into the systemic circulation, limiting access to the lymph nodes. Often, this results in a failure to realize the full potential of the immune response. Worse yet, it can lead to the development of dangerous toxicities at other sites in the body. Elicio Therapeutics’ Novel Approach Founded in 2011, Elicio Therapeutics, Inc. (NASDAQ: ELTX) is developing treatment options aimed at significantly improving the quality of life for cancer patients through the utilization of precision vaccines, immunomodulators and cell-based therapies to potentially assemble cancer-killing immune responses against solid tumors. The company is optimistic about the potential of lymph node-targeting made possible by applying the natural trafficking pathways of larger molecules. This approach differentiates Elicio from its competitors and could be highly promising for enhancing anti-tumor immune responses and improving therapeutic efficacy. Developed at the Massachusetts Institute of Technology (MIT), the company’s proprietary Amphiphile or “AMP” platform, which combines expertise in materials science and immunology, is being used to develop novel immunotherapies, including cell therapy activators, immunomodulators, adjuvants and vaccines for an array of aggressive cancers and infectious diseases. Here’s how it works: The AMP platform is designed to deliver therapeutic payloads directly to critical immune cells in the lymph nodes, enhancing the cancer-fighting mechanisms of the immune system. By delivering cancer immunotherapies to the center of the immune response, this approach is intended to optimize the natural ability of the lymph nodes to educate, activate and amplify cancer-specific T cells. Engineered to coordinate immunity in these uniquely potent sites, the AMP platform was built to amplify the magnitude, potency, quality and durability of the immune response to drive antitumor activity. At the injection site, the platform prevents detrimental payload delivery to systemic circulation, instead guiding the payloads into the lymphatics to promote lymph node delivery. Additionally, it preserves the structural integrity and activity of payloads by preventing any degradation prior to uptake by lymph node resident immune cells. Upon reaching the lymph nodes, the platform optimizes retention and directs the delivery of payloads to key immune cells responsible for the coordination of immune responses, specifically the activation and amplification of cancer-specific immune cells in lymph nodes. Overall, Elicio Therapeutics anticipates that the AMP platform could potentially provide a better quality of life to patients during treatment. The strategy is set apart from other treatments by its ability to activate immune mechanisms directly in the lymph nodes. Enhanced T cell infiltration into tumors, improved T cell expansion and persistence, potent anti-tumor T cell function and wide breadth of response are key attributes with the potential to improve efficacy and reduce the risk of resistance to therapy. Moving forward, Elicio Therapeutics is committed to developing its lymph node-targeting approach for deployment across a range of vaccines, immunomodulators and adjuvants — training the immune system to put the best cells forward to fight a broad spectrum of cancers. Featured photo by National Cancer Institute on Unsplash. Benzinga is a leading financial media and data provider, known for delivering accurate, timely, and actionable financial information to empower investors and traders. This post contains sponsored content. This content is for informational purposes only and is not intended to be investing advice. Contact Details Benzinga +1 877-440-9464 info@benzinga.com Company Website http://www.benzinga.com

April 05, 2024 08:15 AM Eastern Daylight Time

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Nexalin Technology unveils positive results of clinical study for Gen-2 tACS device

Nexalin Technology

Nexalin Technology CEO Mark White joined Steve Darling from Proactive to share positive results from a clinical study evaluating Nexalin’s Gen-2 tACS device for reducing pain in veteran patients with Mild Traumatic Brain Injury (mTBI). The study was conducted at The University of California, San Diego, and involved collaboration with the United States Department of Veterans Affairs (VA) San Diego Healthcare System, as well as the Radiology, Psychiatry, and Neurosciences Departments of UC San Diego. mTBI is a significant concern for veterans and the general public, leading to various physical, cognitive, emotional, and behavioral deficits. However, effective treatments for post-concussive symptoms (PCS) are limited, and the underlying pathophysiology is not fully understood. Symptoms of PCS often overlap with those of post-traumatic stress disorder (PTSD), further complicating diagnosis and treatment. The clinical trial was conducted as a randomized, double-blind, placebo-controlled study over an eight-week period, involving two groups: an active tACS group and a sham tACS group. Twenty-four veteran patients with mTBI received twelve sessions of either active or sham tACS over four consecutive weeks, followed by a four-week follow-up period to assess outcomes. The positive results from this study are significant, especially considering the substantial market potential for treatments addressing traumatic brain injuries. According to Global Market Insights, the Traumatic Brain Injuries Assessment Market is projected to reach over $7.2 billion by 2032. Nexalin's innovative approach offers promise in addressing the needs of individuals suffering from mTBI, potentially improving their quality of life and providing hope for effective treatment options in the future. Contact Details Proactive North America Proactive North America +1 604-688-8158 NA-editorial@proactiveinvestors.com

April 04, 2024 11:05 AM Eastern Daylight Time

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Classiq and Quantum Intelligence Corp (QIC, Korea) Partner On Quantum Accelerated Drug Development

Classiq Technologies

Classiq, a leading quantum computing software company, and Quantum Intelligence Corp. ( QIC, Korea ) today announced the launch of innovative joint research to accelerate drug development by applying quantum computing to pharmacology. The collaboration is under the auspices of Classiq’s Quantum Computing For Life Sciences & Healthcare Center, launched with NVIDIA last year. This new partnership is dedicated to utilizing the Classiq platform to explore the use of quantum computing in pharmacology for a wide range of predictive and analytical applications. This includes the discovery and design of novel drug candidates as well as the prediction of potential side effects and interactions. The partnership focuses on significantly enhancing the efficiency and accuracy of drug development by integrating Classiq's quantum computing platform with QIC's drug development platform. “Quantum Intelligence diverges from the traditional route of biopharmaceutical companies, positioning itself more as a platform company powered by quantum and AI technology,” stated QIC's CEO, Hwanho Choi, MD., PhD. “Through this unique collaborative approach, we aim to precisely identify potential side effects early on, reducing risks across all stages of drug development and clinical trials.” QIC, a South Korean startup pioneering the QUEST-ADMET platform based on quantum computing and AI technologies, targets prediction of compound properties through electronic charge distribution algorithms, to efficiently assess therapeutic solution efficacy and safety of drug candidates. Classiq offers a leading quantum development platform with unique technology enabling high-level abstraction that simplifies and accelerates development of efficient complex quantum software and applications. The Classiq platform’s built-in functions, GitHub repository and seamless execution on quantum computing hardware, will be key components in the research to develop pharmacology applications for research. “This agreement marks a significant step towards a new era of accelerated drug development using quantum computing technology,” said Classiq’s CEO Nir Minerbi. “By combining Classiq's quantum computing technology with QIC's drug development platform, we target significant improvements in the efficiency and accuracy of drug development.” About Classiq Classiq Technologies, the leading quantum software company, provides an all-encompassing platform (IDE, compiler and OS) with a single point of entry into quantum computing, taking users from algorithm design to execution. The high-level descriptive quantum software development environment, tailored to all levels of developer proficiency, automates quantum programming. This ensures that a broad range of talents, including those with backgrounds in AI, ML and linear algebra, can harness quantum computing without requiring deep, specialized knowledge of quantum physics. Classiq democratizes access to quantum computing and equips its users to take full advantage of the quantum computing revolution, including access to a broad range of quantum hardware. Classiq’s core technology, algorithmic quantum circuit compilation, is engineered to power the quantum ecosystem of today and the future. Classiq works closely with quantum cloud providers and advanced computation hardware developers providing software for use with quantum computers, HPC and quantum simulators. Backed by investors such as HPE, HSBC, Samsung, Intesa Sanpaolo and NTT, Classiq’s world-class team of scientists and engineers has distilled decades of quantum expertise into its groundbreaking quantum engine. Follow Classiq on LinkedIn, X (formerly Twitter) or YouTube, and visit the Slack community and website, www.classiq.io to learn more. About Quantum Intelligence Corp. (QIC) Founded in 2020 by CEO Dr. Choi Hwanho and CTO Dr. Kang Hong-seok, Quantum Intelligence Corp. (QIC), based in Seoul, South Korea, is at the forefront of integrating quantum computing with artificial intelligence to revolutionize drug discovery. Using its advanced QUEST-ADMET platform and the Quantum-Dock module, QIC aims to outperform conventional drug development approaches in both accuracy and speed, offering highly precise predictions of drug efficacy and safety. QIC's global expansion is supported by strategic partnerships, including collaborations with Oxford Quantum Circuits (UK), Quandela (France), and QuEra Computing (US), alongside a joint venture with 48Hour Discovery (Canada). These partnerships enhance QIC's presence in key North American, European and Asian markets. The collaborations are aimed at improving pharmacological predictions, discovering new drug candidates and investigating metalloprotein-ligand interactions and pharmacokinetics. Beyond healthcare, QIC is also exploring quantum computing's potential in the financial sector, aiming to transform algorithmic trading, risk analysis and asset management. QIC's diverse team of experts in quantum physics, molecular modeling and AI is committed to driving innovations that optimize the drug development process. These efforts have established QIC as a prospective leader in quantum drug discovery, aiming to reduce development costs and timelines while improving drug safety and efficacy. The company's strategy to license out drug candidates developed with its quantum computing technology marks a paradigm shift in the pharmaceutical industry, underscoring Quantum Intelligence's potential for significant growth. Contact Details Rainier Communications on behalf of Classiq Michelle Allard McMahon classiqPR@rainierco.com Quantum Intelligence Corp. (QIC) Byung-Hoon Kim, Operations Manager hoon.kim@qic.ai Company Website http://www.classiq.io/

April 04, 2024 08:00 AM Eastern Daylight Time

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